Association between Neutrophilic Granulocyte Percentage and Diabetes Mellitus in Cushing’s Syndrome Patients: A Cross-Sectional Study

Table 1

General characteristics of Cushing’s syndrome patients with or without diabetes.

Variables	All (n = 150)	Non-DM (n = 92)	DM (n = 58)	value
Age (years)	50.7 ± 13.8	48.4 ± 14.3	54.2 ± 12.2	0.012
Gender (M/F)	31/119	15/77	16/42	0.300
BMI (kg/m^2)	25.0 ± 3.8	25.0 ± 3.9	25.1 ± 3.7	0.934
Triglyceride (mmol/L)	1.7 ± 1.3	1.4 ± 0.9	2.1 ± 1.6	0.002
FBG (mmol/L)	6.3 ± 2.7	5.0 ± 0.6	8.4 ± 3.4	<0.001
2hPG (mmol/L)	10.3 ± 4.3	7.4 ± 1.2	15.0 ± 3.4	<0.001
HbA1c (%)	6.6 ± 2.0	5.5 ± 0.4	8.3 ± 2.3	<0.001
8 AM cortisol (nmol/L)	543.9 (378.3–762.8)	510.8 (348.9–689.7)	641.4 (436.1–889.6)	0.002
4 PM cortisol (nmol/L)	473.2 (287.3–651.8)	413.7 (219.3–606.8)	544.4 (324.0–866.1)	0.002
12 MN corstisol (nmol/L)	396.9 (211.3–578.9)	357.1 (175.9–553.8)	458.2 (289.0–703.1)	0.008
LDDST cortisol (nmol/L)	232.0 (128.0–484.0)	288.0 (139.0–576.0)	147.0 (123.0–410.0)	0.230
WBC (×10^9)	7.1 ± 2.5	6.7 ± 2.2	7.8 ± 2.7	0.008
Neutrophils (×10^9)	5.1 ± 2.4	4.6 ± 2.1	5.86 ± 2.6	<0.001
NEUT%	68.4 ± 11.8	65.2 ± 11.1	73.6 ± 11.1	<0.001
Lymphocytes (×10^9)	1.5 ± 0.6	1.6 ± 0.4	1.4 ± 0.7	0.055
LYM%	23.0 ± 10.1	25.6 ± 9.5	18.8 ± 9.7	<0.001
Scr (μmol/L)	67.4 ± 36.8	66.3 ± 35.3	69.2 ± 39.1	>0.05
eGRF (ml/min/1.73 m^2)	91 ± 25	93 ± 22	86 ± 29	>0.05
TC (mmol/L)	5.06 ± 1.55	4.94 ± 1.00	5.26 ± 2.13	>0.05
LDL-C (mmol/L)	2.86 ± 0.95	2.85 ± 0.89	2.87 ± 1.03	>0.05
HDL-C (mmol/L)	1.38 ± 0.41	1.45 ± 0.38	1.25 ± 0.42	>0.05

Data are means ± SD, median (interquartile range), and log-transformed for the t-test. BMI, body mass index; FBG, fasting blood glucose; 2hPG, 2-hour postprandial blood glucose; HbA1c, glycosylated hemoglobin; WBC, white blood cell; NEUT%, neutrophilic granulocyte percentage; LYM%, lymphocyte percentage; Scr, serum creatinine; eGRF, estimated glomerular filtration rate; TC, total cholesterol; LDL-C, low-density lipoprotein cholesterin; HDL-C, high-density lipoprotein cholesterin.