Differences in Clinicopathological Characteristics of Papillary Thyroid Carcinoma between Symptomatic and Asymptomatic Patients with Primary Hyperparathyroidism

Table 1

Comparison of clinical feature and laboratory values between asymptomatic PHPT patients and symptomatic PHPT patients.

	Total PHPT (N = 304)	Asymptomatic PHPT (N = 123)	Symptomatic PHPT (N = 181)	value
Age	53.27 ± 13.54	53.68 ± 12.53	53.00 ± 14.62	0.67
Female/male ratio	2.49 : 1	3.24 : 1	2.12 : 1	0.12
Calcium (mmol/L)	2.93 (2.62–4.97)	2.77 (2.62–3.46)	3.12 (2.66–4.97)	<0.001
Albumin-corrected calcium (mmol/L)	2.87 (2.51–5.04)	2.68 (2.51–3.81)	3.11 (2.56–5.04)	<0.001
Phosphate (mmol/L)	0.75 ± 0.21	0.83 ± 0.16	0.69 ± 0.22	<0.001
Magnesium (mmol/L)	0.88 (0.4–1.11)	0.92 (0.7–1.06)	0.84 (0.4–1.11)	<0.001
Potassium (mmol/L)	4.18 (2.6–5.44)	4.22 (3.21–5.44)	4.13 (2.6–5.27)	<0.001
Sodium, mmol/L)	141 (131–151)	141 (135–147)	141 (131–151)	0.93
Chlorine (mmol/L)	107 (94–119)	107 (96–116)	108 (94–119)	0.02
ALP (U/L)	125 (41–2644)	101 (44–405)	152 (41–2644)	<0.001
PTH (pg/mL)	303.95 (30.63–4595)	170.10 (30.63–1666)	552.5 (34.54–4595)	<0.001
25 (OH)D (ng/mL)	11.35 (3–32.34)	14.20 (3–32.34)	9.30 (3–27.75)	0.02
N-BGP (ng/mL)	61.10 (14.21–300)	37.76 (14.21–188.30)	92.76 (19.3–300)	<0.001
β-CTx (ng/mL)	1.18 (0.19–6.00)	0.90 (0.29–3.61)	1.48 (0.19–6.00)	<0.001
TP1NP (ng/mL)	108.40 (9.55–1200)	80.98 (23.13–154.80)	125.85 (9.55–1200)	<0.001

PHPT, primary hyperparathyroidism; ALP, alkaline phosphatase; PTH, parathyroid hormone; 25 (OH)D, 25-hydroxyvitamin D; N-BGP, N-bone Gla-protein; β-CTx, β-isomerized C-terminal telopeptides; TP1NP, total procollagen type 1 amino-terminal propeptide.