Relationship of Serum Total Insulin-Like Growth Factor Binding Protein-3 with Insulin-Like Growth Factor-I and Glucose Tolerance in Korean Children and Adolescents
Table 3
Clinical characteristics of the study subjects with glucose intolerance according to BMI.
Characteristic
Total
Normal
Overweight
Obesity
value
Number (%)
72 (100.0)
23 (31.9)
12 (16.7)
37 (51.4)
Sex (male/female)
25/47
8/15
5/7
12/25
0.812
Age (yr)
13.72 ± 2.88
15.32 ± 2.47
13.13 ± 3.08†
12.92 ± 2.71†
0.004
BMI (kg/m2)
25.39 ± 5.68
20.41 ± 2.91
23.05 ± 5.03
29.24 ± 4.22†
<0.001
HbA1c (%)
7.66 ± 2.40
7.98 ± 2.92
7.55 ± 2.37
7.49 ± 2.10
0.743
Systolic BP (mmHg)
124.61 ± 16.44
117.48 ± 14.31
132.55 ± 15.59†
126.75 ± 16.63†
0.021
Diastolic BP (mmHg)
72.54 ± 11.94
70.87 ± 11.89
70.27 ± 7.43
74.31 ± 13.02
0.448
FPG (mg/dL)
146.10 ± 72.86
156.52 ± 75.47
150.08 ± 67.18WSY
138.32 ± 73.98
0.635
2 hr PLG (mg/dL)
277.35 ± 162.13
309.35 ± 142.62
319.08 ± 269.74
243.92 ± 121.64
0.197
C-peptide (ng/mL)
3.21 ± 1.85
1.87 ± 0.82
3.85 ± 2.32†
3.85 ± 1.73†
<0.001
Insulin (μU/mL)
23.14 ± 24.12
9.04 ± 5.08
30.16 ± 27.33†
29.06 ± 26.77†
0.013
HOMA-IR
7.86 ± 8.10
4.08 ± 3.45
9.02 ± 7.07†
9.63 ± 9.52†
0.067
Lipid profile
Cholesterol (mg/dL)
176.47 ± 34.25
169.87 ± 40.92
183.33 ± 30.46
178.35 ± 30.98
0.491
Triglyceride (mg/dL)
137.57 ± 72.12
95.09 ± 44.26
147.50 ± 68.86†
160.76 ± 76.64†
0.002
HDL (mg/dL)
44.49 ± 10.06
48.74 ± 13.63
45.42 ± 8.11†
41.54 ± 6.74†
0.023
LDL (mg/dL)
107.81 ± 31.90
100.26 ± 41.53
111.67 ± 21.12
111.24 ± 27.63
0.394
IGF-I (ng/mL)
404.84 ± 160.67
409.49 ± 123.89
441.71 ± 157.09
391.76 ± 182.44
0.682
IGFBP-3 (ng/mL)
6463.64 ± 1199.37
6390.00 ± 1079.20
6206.00 ± 1487.64
6587.06 ± 1203.85
0.643
IGF-I/IGFBP-3 ratio
0.0625 ± 0.0234
0.0646 ± 0.0187
0.712 ± 0.0233
0.0587 ± 0.0259
0.298
The data are presented as mean ± SD values. BMI, body mass index; BP, blood pressure; HbA1c, glycosylated hemoglobin; FPG, fasting plasma glucose; 2 hr PLG, 2-hour postload glucose; HOMA-IR, homeostasis model assessment of insulin resistance; LDL, low-density lipoprotein; HDL, high-density lipoprotein; IGF-I, insulin-like growth factor-I; IGFBP-3, insulin-like growth factor binding protein-3; SD, standard deviation. , †, ‡The same superscript indicates that there is no significant difference between the groups based on the Tukey multiple comparison test.
