Sestrin2 Overexpression Ameliorates Endoplasmic Reticulum Stress-Induced Apoptosis via Inhibiting mTOR Pathway in HepG2 Cells

Figure 6

Sestrin2 overexpression inhibits TM-induced mTOR pathway activation. (a) Representative western-blot results of major proteins associated with mTOR pathway. (b) Statistical analysis of p-mTOR, mTOR and their ratio (unpaired two-tailed t-test; all values >0.05). (c) Statistical results of p-P70S6K, P70S6K and their ratio (unpaired two-tailed t-test; for p-p70s6k/p70s6k: t₍₄₎ = 3.30, ). (d) Quantitative results of p-4E-BP1, 4E-BP1 and their ratio (unpaired two-tailed t-test; for 4E-BP1: t₍₄₎ = 3.62, ). .

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