Resveratrol Alleviates Skeletal Muscle Insulin Resistance by Downregulating Long Noncoding RNA

Table 4

Top 30 significantly differential expression mRNAs in mice.

Gene name	log2FC (HFD versus CON)	value (HFD versus CON)	Up/down (HFD versus CON)	log2FC (HFD + RSV versus HFD)	value (HFD + RSV versus HFD)	Up/down (HFD + RSV versus HFD)
Gm49388	6.06138	1.92E−10	Up	−2.53021	0.044372	Down
Gm26876	3.811306	7.03E−09	Up	−3.11381	5.15E−07	Down
4930512H18Rik	3.787461	3.47E−18	Up	−1.20868	0.003987	Down
Gm29676	3.283294	0.00530139	Up	−3.86133	0.002862	Down
Map6d1	3.074208	0.007729399	Up	−1.72651	0.047048	Down
Ppm1n	3.000682	2.93E−08	Up	−1.05825	0.012598	Down
Sh3gl2	2.803522	1.83E−09	Up	−2.08107	5.64E−06	Down
Clca4a	2.729295	0.000758257	Up	−2.14669	0.002907	Down
Gm49347	2.69398	0.016676861	Up	−2.79388	0.016914	Down
Gm33543	2.661545	2.23E−13	Up	−1.30568	0.029604	Down
Ccl12	2.641596	0.005800303	Up	−3.96508	0.00141	Down
Gm9402	2.633552	0.044305865	Up	−2.95627	0.046539	Down
Gm48719	2.618363	1.87E−05	Up	−1.43542	0.008835	Down
Rpl21-ps12	2.537707	0.000902295	Up	−1.83961	0.012602	Down
Gm15478	2.466703	1.04E−05	Up	−1.16718	0.029683	Down
Kcnh7	2.453351	3.86E−11	Up	−1.11192	0.016375	Down
Socs1	2.44948	4.05E−07	Up	−2.36143	1.61E−06	Down
Gm47603	2.39615	2.51E−05	Up	−1.36179	0.007302	Down
C130026L21Rik	2.31491	0.023709939	Up	−2.52323	0.024031	Down
AY036118	2.26368	0.014427254	Up	−2.08364	0.022577	Down
Cish	2.1587	1.43E−14	Up	−2.48736	1.64E−20	Down
Cd209e	2.146486	0.001095503	Up	−1.52077	0.033734	Down
Dkk3	2.060882	1.16E−07	Up	−1.51887	0.000588	Down
Pou2f3	2.046599	0.032113693	Up	−2.67227	0.010465	Down
Pcsk1	1.960889	6.87E−07	Up	−1.14143	0.001394	Down
Gm26635	1.857674	0.020348988	Up	−1.53523	0.040218	Down
B230312C02Rik	1.846494	1.97E−10	Up	−1.85503	2.38E−10	Down
4932438H23Rik	1.740581	0.019356615	Up	−1.8725	0.019401	Down
Ccl7	1.669165	0.006830603	Up	−1.92417	0.005174	Down
Megf11	1.597213	0.002069216	Up	−1.26422	0.028085	Down
Sox10	−1.00199	0.00499603	Down	1.277467	0.008898	Up
Gm17971	−1.01911	0.001132241	Down	1.082473	0.012236	Up
Mgat3	−1.02613	0.002140658	Down	1.038285	0.007315	Up
Gas2l3	−1.02807	0.020453198	Down	1.139046	0.006303	Up
Bcas1	−1.04182	0.015404068	Down	1.7179	0.002295	Up
Asphd2	−1.04528	0.020154215	Down	1.010603	0.025998	Up
Gm37537	−1.05529	0.004647624	Down	1.013631	0.014094	Up
Fos	−1.07258	0.000205959	Down	1.126982	0.002405	Up
Gldn	−1.07534	0.029747688	Down	1.119705	0.011748	Up
Pmp22	−1.10369	0.0243704	Down	1.272211	0.007779	Up
Sptbn5	−1.10708	0.002406818	Down	1.274	0.003898	Up
Plekha4	−1.11677	0.003070017	Down	1.306669	0.002928	Up
Kcna6	−1.11915	0.010919737	Down	1.15063	0.011805	Up
Gabrr1	−1.12133	0.007296347	Down	1.004214	0.027277	Up
Mir1904	−1.12175	0.004769582	Down	1.111331	0.011967	Up
Kif19a	−1.14672	0.006248502	Down	1.502258	0.001265	Up
Fosl2	−1.16247	1.85E−08	Down	1.02334	4.21E−05	Up
Lrrc71	−1.16508	0.023094219	Down	1.001178	0.048202	Up
Fhl4	−1.1723	0.034470511	Down	1.121767	0.045133	Up
Fa2h	−1.18303	0.034450796	Down	1.299243	0.029667	Up
Gm37510	−1.19184	0.004453269	Down	1.03012	0.008302	Up
Ppia	−1.19672	0.001831193	Down	1.119291	2.62E−05	Up
Tnfsf13b	−1.20579	0.016517031	Down	1.142204	0.010129	Up
Tox	−1.21833	0.015176461	Down	1.414292	0.001254	Up
Rasgef1c	−1.2224	0.036363327	Down	1.405989	0.013403	Up
Mt3	−1.22738	0.007211092	Down	1.291177	0.005362	Up
Elovl7	−1.24473	0.016851444	Down	1.412536	0.009919	Up
Wnt2b	−1.26686	0.007582771	Down	1.527884	0.008061	Up
Tenm2	−1.27034	0.005050296	Down	1.05799	0.010664	Up
Mmp27	−1.27782	0.027735632	Down	1.191382	0.04508	Up

The table lists the top 30 of the results for mRNA with upregulation or downregulation in expression in three groups. HFD: high-fat diet; CON: control; RSV: resveratrol; lncRNA: long noncoding RNA.