Harmful Consequences of Proton Pump Inhibitors on Male Fertility: An Evidence from Subchronic Toxicity Study of Esomeprazole and Lansoprazole in Wistar Rats
Table 1
Effect of treatment with esomeprazole (ES) and lansoprazole (LN) on sperm motility in male rats.
Groups
Total motility (%)
Progressive motility (%)
Curvilinear velocity (μm/s)
Straight line velocity (μm/s)
Average path velocity (μm/s)
Linearity (%)
Control
77.60 ± 0.83
63.73 ± 1.47
151.26 ± 23.84
110.04 ± 15.76
115.27 ± 15.87
0.73 ± 0.01
ES 2.5 mg/kg/day
48.67 ± 2.22
29.16 ± 1.41
79.40 ± 10.05
63.88 ± 9.90
66.62 ± 10.19
0.80 ± 0.02
ES 5 mg/kg/day
53.14 ± 1.89
40.53 ± 0.22
124.72 ± 2.53
99.10 ± 5.26
102.66 ± 7.23
0.79 ± 0.01
ES 10 mg/kg/day
50.27 ± 1.99
41.60 ± 0.34
110.72 ± 3.53
85.92 ± 2.42
89.49 ± 2.67
0.77 ± 0.005
LN 2.5 mg/kg/day
60.56 ± 1.74
49.31 ± 1.51
135.32 ± 5.26
101.91 ± 5.71
105.72 ± 5.78
0.75 ± 0.01
LN 5 mg/kg/day
62.19 ± 2.06
43.25 ± 1.17
96.78 ± 12.77
75.18 ± 12.07
79.04 ± 11.79
0.77 ± 0.02
LN 10 mg/kg/day
61.20 ± 2.38
47.58 ± 2.56
121.86 ± 19.80
90.93 ± 15.38
94.98 ± 15.61
0.74 ± 0.005
Results are shown as mean ± standard deviation. ,,, and showed significant results at , and 0.0001 in contrast to the normal control group.
