Harmful Consequences of Proton Pump Inhibitors on Male Fertility: An Evidence from Subchronic Toxicity Study of Esomeprazole and Lansoprazole in Wistar Rats

Table 2

Effect of treatment with esomeprazole (ES) and lansoprazole (LN) on sperm count and testes weight in male rats.

Treatments	Sperm count (millions/ml)	Testes weight (g)
Normal control	74 ± 2	0.930 ± 0.172
ES 2.5 mg/kg/day	46 ± 3	0.853 ± 0.170
ES 5 mg/kg/day	42 ± 3	0.863 ± 0.134
ES 10 mg/kg/day	28 ± 2	0.856 ± 0.152
LN 2.5 mg/kg/day	45 ± 2	0.894 ± 0.162
LN 5 mg/kg/day	40 ± 2	0.882 ± 0.133
LN 10 mg/kg/day	32 ± 2	0.786 ± 0.146

Results are shown as mean ± standard deviation. showed statistical difference in contrast to the normal control group.