SLC2A9 rs1014290 Polymorphism is Associated with Prediabetes and Type 2 Diabetes

Table 1

Comparison of the general data and biochemical parameters for the control, prediabetic, and type 2 diabetic groups.

Variables	Groups			Pairwise comparisons
	Controls (n = 348)	Pre-DM (n = 358)	T2DM (n = 352)	All P	P1	P2
Age (years)	42.8 ± 13.05	52.56 ± 12.32	59.1 ± 10.23	<0.001	<0.001	<0.001
Male/female (n)	145/203	165/193	159/193	0.372	0.180	0.291
BMI (kg/m^2)	25.09 ± 3.83	26.99 ± 3.84	26.89 ± 3.71	<0.001	<0.001	<0.001
SBP (mmHg)	124.03 ± 14.12	127.13 ± 13.39	131.42 ± 13.20	<0.001	0.002	<0.001
DBP (mmHg)	76.43 ± 9.52	77.14 ± 9.28	78.18 ± 8.86	0.041	0.306	0.012
UA (umol/L)	241.34 ± 45.8	319.76 ± 37.6	448.08 ± 73.41	<0.001	<0.001	<0.001
TG (mmol/L)	1.37 ± 0.98	1.76 ± 1.45	1.94 ± 1.98	<0.001	0.001	<0.001
TC (mmol/L)	4.60 ± 0.91	4.98 ± 0.96	5.07 ± 1.04	<0.001	<0.001	<0.001
HDL (mmol/L)	1.37 ± 0.32	1.27 ± 0.25	1.30 ± 0.31	<0.001	<0.001	0.014
LDL (mmol/L)	2.79 ± 0.71	3.08 ± 0.78	2.97 ± 0.85	<0.001	<0.001	0.007
FPG (mmol/L)	5.00 ± 0.36	5.76 ± 0.59	7.83 ± 1.84	<0.001	<0.001	<0.001
PBG (mmol/L)	5.47 ± 1.03	8.20 ± 1.33	12.71 ± 2.72	<0.001	<0.001	<0.001
FINS (μU/mL)	9.91 ± 3.57	9.00 ± 3.22	7.80 ± 2.78	<0.001	0.001	<0.001
Postprandial FINS (μU/mL)	44.10 ± 22.95	65.26 ± 22.13	47.64 ± 16.13	<0.001	0.001	0.023
HbA1c (%)	5.55 ± 0.34	5.77 ± 0.38	7.33 ± 1.51	<0.001	<0.001	<0.001
HOMA-IR	2.20 ± 0.82	2.31 ± 0.89	2.70 ± 1.13	<0.001	0.221	<0.001
HOMA-β	139.89 ± 67.95	85.55 ± 40.11	43.11 ± 24.48	<0.001	<0.001	<0.001

Notes. P1, pre-DM vs. controls; P2, T2DM vs. controls.