Research Article
SLC2A9 rs1014290 Polymorphism is Associated with Prediabetes and Type 2 Diabetes
Table 1
Comparison of the general data and biochemical parameters for the control, prediabetic, and type 2 diabetic groups.
| Variables | Groups | Pairwise comparisons | Controls (n = 348) | Pre-DM (n = 358) | T2DM (n = 352) | All P | P1 | P2 |
| Age (years) | 42.8 ± 13.05 | 52.56 ± 12.32 | 59.1 ± 10.23 | <0.001 | <0.001 | <0.001 | Male/female (n) | 145/203 | 165/193 | 159/193 | 0.372 | 0.180 | 0.291 | BMI (kg/m2) | 25.09 ± 3.83 | 26.99 ± 3.84 | 26.89 ± 3.71 | <0.001 | <0.001 | <0.001 | SBP (mmHg) | 124.03 ± 14.12 | 127.13 ± 13.39 | 131.42 ± 13.20 | <0.001 | 0.002 | <0.001 | DBP (mmHg) | 76.43 ± 9.52 | 77.14 ± 9.28 | 78.18 ± 8.86 | 0.041 | 0.306 | 0.012 | UA (umol/L) | 241.34 ± 45.8 | 319.76 ± 37.6 | 448.08 ± 73.41 | <0.001 | <0.001 | <0.001 | TG (mmol/L) | 1.37 ± 0.98 | 1.76 ± 1.45 | 1.94 ± 1.98 | <0.001 | 0.001 | <0.001 | TC (mmol/L) | 4.60 ± 0.91 | 4.98 ± 0.96 | 5.07 ± 1.04 | <0.001 | <0.001 | <0.001 | HDL (mmol/L) | 1.37 ± 0.32 | 1.27 ± 0.25 | 1.30 ± 0.31 | <0.001 | <0.001 | 0.014 | LDL (mmol/L) | 2.79 ± 0.71 | 3.08 ± 0.78 | 2.97 ± 0.85 | <0.001 | <0.001 | 0.007 | FPG (mmol/L) | 5.00 ± 0.36 | 5.76 ± 0.59 | 7.83 ± 1.84 | <0.001 | <0.001 | <0.001 | PBG (mmol/L) | 5.47 ± 1.03 | 8.20 ± 1.33 | 12.71 ± 2.72 | <0.001 | <0.001 | <0.001 | FINS (μU/mL) | 9.91 ± 3.57 | 9.00 ± 3.22 | 7.80 ± 2.78 | <0.001 | 0.001 | <0.001 | Postprandial FINS (μU/mL) | 44.10 ± 22.95 | 65.26 ± 22.13 | 47.64 ± 16.13 | <0.001 | 0.001 | 0.023 | HbA1c (%) | 5.55 ± 0.34 | 5.77 ± 0.38 | 7.33 ± 1.51 | <0.001 | <0.001 | <0.001 | HOMA-IR | 2.20 ± 0.82 | 2.31 ± 0.89 | 2.70 ± 1.13 | <0.001 | 0.221 | <0.001 | HOMA-β | 139.89 ± 67.95 | 85.55 ± 40.11 | 43.11 ± 24.48 | <0.001 | <0.001 | <0.001 |
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Notes. P1, pre-DM vs. controls; P2, T2DM vs. controls.
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