SLC2A9 rs1014290 Polymorphism is Associated with Prediabetes and Type 2 Diabetes

Table 5

Comparisons of biochemical indices of the SLC2A9 A/G (rs1014290) SNP among the different genotypes in the pre-DM group.

Variables	Genotype groups			Pairwise comparisons
	AA (n = 115)	AG (n = 180)	GG (n = 63)	All P	P1	P2	P3
Age (years)	52.88 ± 11.77	54.26 ± 11.27	51.08 ± 11.51	0.153	0.313	0.318	0.059
Male/female (n)	53/62	84/96	28/35	0.955	0.922	0.833	0.761
BMI (kg/m^2)	27.06 ± 3.70	27.09 ± 3.89	26.57 ± 3.98	0.636	0.958	0.414	0.359
SBP (mmHg)	127.5 ± 14.02	128.15 ± 12.90	123.52 ± 13.16	0.057	0.685	0.057	0.018
DBP (mmHg)	77.18 ± 9.23	76.96 ± 9.27	77.59 ± 9.54	0.898	0.842	0.782	0.646
UA (umol/L)	316.78 ± 26.76	320.08 ± 45.59	321.41 ± 23.79	0.667	0.457	0.426	0.806
TG (mmol/L)	1.63 ± 1.08	1.89 ± 1.74	1.65 ± 1.06	0.260	0.140	0.956	0.252
TC (mmol/L)	5.02 ± 0.94	5.02 ± 0.97	4.78 ± 0.98	0.202	0.972	0.110	0.092
HDL (mmol/L)	1.25 ± 0.23	1.30 ± 0.26	1.26 ± 0.23	0.223	0.094	0.698	0.341
LDL (mmol/L)	3.16 ± 0.81	3.05 ± 0.78	3.01 ± 0.73	0.415	0.275	0.241	0.714
FPG (mmol/L)	6.45 ± 0.30	5.61 ± 0.21	4.91 ± 0.22	<0.001	<0.001	<0.001	<0.001
PBG (mmol/L)	7.49 ± 1.73	8.47 ± 0.91	8.69 ± 0.95	<0.001	<0.001	<0.001	0.222
FINS (μU/mL)	9.50 ± 3.29	8.63 ± 3.07	9.16 ± 3.44	0.071	0.024	0.492	0.265
Postprandial FINS (μU/mL)	60.64 ± 21.67	67.29 ± 20.85	67.91 ± 25.35	0.024	0.012	0.036	0.848
HbA1c (%)	5.79 ± 0.43	5.78 ± 0.36	5.71 ± 0.37	0.350	0.763	0.163	0.212
HOMA-IR	2.73 ± 0.96	2.15 ± 0.78	2.00 ± 0.77	<0.001	<0.001	<0.001	0.521
HOMA-β	64.93 ± 23.00	82.50 ± 30.22	131.94 ± 51.47	<0.001	<0.001	<0.001	<0.001

Notes. P1, GA vs. AA; P2, GG vs. AA; P3, GG vs. GA.