Research Article
SLC2A9 rs1014290 Polymorphism is Associated with Prediabetes and Type 2 Diabetes
Table 6
Comparison of biochemical indices of the SLC2A9 A/G (rs1014290) SNP among the different genotypes in the T2DM group.
| Variables | Genotype groups | Pairwise comparisons | AA (n = 128) | AG (n = 172) | GG (n = 52) | All P | P1 | P2 | P3 |
| Age (years) | 58.84 ± 10.48 | 59.41 ± 10.38 | 58.71 ± 9.20 | 0.857 | 0.638 | 0.938 | 0.668 | Male/female (n) | 66/62 | 71/101 | 22/30 | 0.187 | 0.095 | 0.174 | 0.850 | BMI (kg/m2) | 27.09 ± 3.47 | 26.88 ± 3.92 | 26.44 ± 3.60 | 0.575 | 0.637 | 0.294 | 0.457 | SBP (mmHg) | 132.79 ± 12.91 | 130.95 ± 12.96 | 129.62 ± 14.56 | 0.277 | 0.232 | 0.144 | 0.524 | DBP (mmHg) | 79.45 ± 8.62 | 77.47 ± 8.28 | 77.42 ± 10.91 | 0.127 | 0.055 | 0.163 | 0.973 | UA (umol/L) | 430.52 ± 45.67 | 441.06 ± 64.30 | 428.56 ± 58.97 | <0.001 | 0.266 | <0.001 | <0.001 | TG (mmol/L) | 2.41 ± 2.98 | 1.74 ± 1.03 | 1.41 ± 0.69 | 0.002 | 0.004 | 0.002 | 0.275 | TC (mmol/L) | 5.22 ± 1.07 | 5.03 ± 1.02 | 4.81 ± 0.94 | 0.045 | 0.127 | 0.016 | 0.164 | HDL (mmol/L) | 1.30 ± 0.32 | 1.30 ± 0.30 | 1.30 ± 0.34 | 0.979 | 0.874 | 0.854 | 0.940 | LDL (mmol/L) | 3.06 ± 0.80 | 2.94 ± 0.87 | 2.84 ± 0.87 | 0.229 | 0.217 | 0.111 | 0.455 | FPG (mmol/L) | 9.85 ± 1.30 | 7.02 ± 0.57 | 5.53 ± 0.30 | <0.001 | <0.001 | <0.001 | <0.001 | PBG (mmol/L) | 14.42 ± 2.09 | 12.24 ± 2.42 | 10.03 ± 2.28 | <0.001 | <0.001 | <0.001 | <0.001 | FINS (μU/mL) | 7.85 ± 2.89 | 7.88 ± 2.82 | 7.41 ± 2.34 | 0.558 | 0.934 | 0.342 | 0.295 | Postprandial FINS (μU/mL) | 43.51 ± 16.41 | 49.40 ± 15.70 | 52.00 ± 14.92 | 0.001 | 0.002 | 0.001 | 0.307 | HbA1c (%) | 8.05 ± 1.67 | 7.12 ± 1.25 | 6.22 ± 0.92 | <0.001 | <0.001 | <0.001 | <0.001 | HOMA-IR | 3.40 ± 1.22 | 2.45 ± 0.88 | 1.82 ± 0.58 | <0.001 | <0.001 | <0.001 | <0.001 | HOMA-β | 26.14 ± 12.03 | 46.24 ± 19.40 | 74.53 ± 27.21 | <0.001 | <0.001 | <0.001 | <0.001 |
|
|
Notes. P1, GA vs. AA; P 2, GG vs. AA; P 3, GG vs. GA.
|