SLC2A9 rs1014290 Polymorphism is Associated with Prediabetes and Type 2 Diabetes

Table 6

Comparison of biochemical indices of the SLC2A9 A/G (rs1014290) SNP among the different genotypes in the T2DM group.

Variables	Genotype groups			Pairwise comparisons
	AA (n = 128)	AG (n = 172)	GG (n = 52)	All P	P1	P2	P3
Age (years)	58.84 ± 10.48	59.41 ± 10.38	58.71 ± 9.20	0.857	0.638	0.938	0.668
Male/female (n)	66/62	71/101	22/30	0.187	0.095	0.174	0.850
BMI (kg/m^2)	27.09 ± 3.47	26.88 ± 3.92	26.44 ± 3.60	0.575	0.637	0.294	0.457
SBP (mmHg)	132.79 ± 12.91	130.95 ± 12.96	129.62 ± 14.56	0.277	0.232	0.144	0.524
DBP (mmHg)	79.45 ± 8.62	77.47 ± 8.28	77.42 ± 10.91	0.127	0.055	0.163	0.973
UA (umol/L)	430.52 ± 45.67	441.06 ± 64.30	428.56 ± 58.97	<0.001	0.266	<0.001	<0.001
TG (mmol/L)	2.41 ± 2.98	1.74 ± 1.03	1.41 ± 0.69	0.002	0.004	0.002	0.275
TC (mmol/L)	5.22 ± 1.07	5.03 ± 1.02	4.81 ± 0.94	0.045	0.127	0.016	0.164
HDL (mmol/L)	1.30 ± 0.32	1.30 ± 0.30	1.30 ± 0.34	0.979	0.874	0.854	0.940
LDL (mmol/L)	3.06 ± 0.80	2.94 ± 0.87	2.84 ± 0.87	0.229	0.217	0.111	0.455
FPG (mmol/L)	9.85 ± 1.30	7.02 ± 0.57	5.53 ± 0.30	<0.001	<0.001	<0.001	<0.001
PBG (mmol/L)	14.42 ± 2.09	12.24 ± 2.42	10.03 ± 2.28	<0.001	<0.001	<0.001	<0.001
FINS (μU/mL)	7.85 ± 2.89	7.88 ± 2.82	7.41 ± 2.34	0.558	0.934	0.342	0.295
Postprandial FINS (μU/mL)	43.51 ± 16.41	49.40 ± 15.70	52.00 ± 14.92	0.001	0.002	0.001	0.307
HbA1c (%)	8.05 ± 1.67	7.12 ± 1.25	6.22 ± 0.92	<0.001	<0.001	<0.001	<0.001
HOMA-IR	3.40 ± 1.22	2.45 ± 0.88	1.82 ± 0.58	<0.001	<0.001	<0.001	<0.001
HOMA-β	26.14 ± 12.03	46.24 ± 19.40	74.53 ± 27.21	<0.001	<0.001	<0.001	<0.001

Notes. P1, GA vs. AA; P 2, GG vs. AA; P 3, GG vs. GA.