Research Article
miR-149-3p Is a Potential Prognosis Biomarker and Correlated with Immune Infiltrates in Uterine Corpus Endometrial Carcinoma
Table 3
Univariate and multivariate Cox regression analysis of OS and clinical features in UCEC patients.
| Characteristics | Total (N) | Univariate analysis | Multivariate analysis | HR (95% CI) | value | HR (95% CI) | value |
| Clinical stage (stage I and stage II versus stage III and stage IV) | 545 | 3.774 (2.484–5.732) | <0.001 | 3.912 (1.711–8.946) | 0.001 | Primary therapy outcome (PD, SD, and PR versus CR) | 475 | 0.125 (0.075–0.208) | <0.001 | 0.299 (0.130–0.689) | 0.005 | Age (≤60 versus >60) | 543 | 2.002 (1.236–3.242) | 0.005 | 1.944 (0.868–4.355) | 0.106 | Weight (≤80 versus >80) | 522 | 1.032 (0.676–1.576) | 0.885 | | | Height (≤160 versus >160) | 518 | 1.115 (0.728–1.708) | 0.616 | | | BMI (≤30 versus >30) | 514 | 0.942 (0.616–1.442) | 0.784 | | | Histological type (mixed and serous versus endometrioid) | 545 | 0.366 (0.241–0.557) | <0.001 | 1.285 (0.615–2.685) | 0.505 | Residual tumor (R0 versus R1 and R2) | 407 | 3.081 (1.725–5.503) | <0.001 | 1.951 (0.811–4.694) | 0.136 | Histologic grade ( versus and ) | 534 | 22.795 (3.172–163.794) | 0.002 | 156521500.831 (0.000-Inf) | 0.997 | Tumor invasion (%) (<50 versus ≥50) | 469 | 3.124 (1.909–5.112) | <0.001 | 1.111 (0.532–2.320) | 0.779 | Menopause status (peri and post versus pre) | 499 | 1.070 (0.466–2.457) | 0.874 | | | Hormones therapy (no versus yes) | 343 | 0.872 (0.412–1.845) | 0.72 | | | Diabetes (no versus yes) | 445 | 1.188 (0.733–1.925) | 0.485 | | | Radiation therapy (no versus yes) | 521 | 0.586 (0.375–0.914) | 0.018 | 0.320 (0.165–0.622) | <0.001 | Surgical approach (minimally invasive versus open) | 522 | 0.731 (0.474–1.127) | 0.156 | | | hsa-miR-149-3p (low versus high) | 545 | 2.559 (1.637–4.002) | <0.001 | 2.393 (1.161–4.935) | 0.018 |
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