Dynamic Alteration of the Gut Microbiota Associated with Obesity and Intestinal Inflammation in Ovariectomy C57BL/6 Mice

Figure 4

Estrogen deficiency leads to an increase in mouse weight and alters the abundance of gut microbiota species related to weight. (a) The boxplot shows the mouse weights of the model and control groups. The weight of the OVX group mice significantly increased compared to that of the control group mice. The p value was calculated by the Wilcoxon rank-sum test and corrected by the BH method. (b) The gut microbiota species were related to mouse weight. The red line represents the gut microbiota species that were positively correlated with mouse weight (Spearman’s correlation coefficient >0.3 and Spearman’s p value < 0.05). In contrast, the blue line represents the species that were negatively associated with mouse weight (Spearman’s correlation coefficient < -0.3 and Spearman p value < 0.05). The blue nodes represent the species that were enriched in the OVX group mice at the T2-T4 time points, while the nodes in light orange represent the irregular enrichment of species at different time points. The node size indicates Spearman’s p value of the gut microbiota species and mouse weight.

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