Metabolic Effects of Recombinant Human Growth Hormone Replacement Therapy on Juvenile Patients after Craniopharyngioma Resection

Table 2

Changes in metabolic parameters for patients with craniopharyngioma after rhGH replacement therapy.

Metabolic parameter	GHRT group (n = 30)			Control group (n = 12)			Change after one year follow-up
	Before	1-year GHRT		Baseline	1-year follow-up		Change for GHRT group	Change for the control group
BMI (kg/m^2)	22.61 ± 5.51	22.14 ± 5.23	0.217	23.78 ± 5.50	24.03 ± 5.82	0.673	−0.47 ± 2.05	0.25 ± 1.99	0.350
BMI z-score	1.60 ± 1.76	1.13 ± 1.73	0.005	2.23 ± 1.37	1.91 ± 1.48	0.095	−0.47 ± 0.84	−0.32 ± 0.60	0.588
Height z-score	−1.98 ± 1.70	−1.21 ± 1.45	≤ 0.001	−0.66 ± 1.61	−0.35 ± 1.36	0.318	0.56 (0.21∼1.37)	0.31 ± 1.03	0.089
IGF-1 (SD)	−2.59 (−2.81∼−2.37)	−1.26 (−1.70∼0.18)	≤ 0.001	−2.57 (−2.61∼−1.57)	−1.99 ± 0.56	0.182	1.36 (1.04∼2.30)	0.25 ± 0.53	≤ 0.001
ALT (U/L)	26.50 (17.00∼98.00)	18.00 (13.0∼26.48)	≤ 0.001	26.58 ± 8.75	42.58 ± 24.59	0.039	−7.00 (−32.5∼−2.0)	16.00 ± 23.62	0.001
AST (U/L)	36.00 (28.00∼65.00)	29.40 (23.00∼35.00)	≤ 0.001	30.00 (27.25∼41.50)	36.42 ± 9.99	0.610	−7.50 (−43.50∼−9.00)	1.17 ± 9.71	0.007
GGT (U/L)	22.00 (14.50∼45.00)	18.50 (12.75∼24.54)	0.001	19.00 (13.25∼29.25)	25.0 (14.75∼34.75)	0.026	−5.00(−20.34∼0.25)	7.00 (1∼19.5)	≤ 0.001
TG (mmol/L)	1.45 (0.71∼2.02)	1.34 (0.81∼1.83)	0.551	1.52 (0.91∼3.44)	1.53 ± 0.60	0.388	−0.26 ± 1.40	−0.33 (−1.03∼0.55)	0.540
TC (mmol/L)	4.67 (4.10∼6.14)	4.32 ± 0.85	0.002	5.14 ± 1.66	4.80 ± 0.74	0.417	−0.65 ± 1.01	−0.34 ± 1.41	0.436
HDL (mmol/L)	1.06 (0.76∼1.42)	1.12 ± 0.33	0.574	0.95 ± 0.27	1.06 ± 0.28	0.073	0.02 ± 0.40	0.10 ± 0.18	0.513
LDL (mmol/L)	3.05 ± 0.95	2.56 ± 0.65	0.001	2.27 ± 0.76	3.43 ± 1.28	0.040	−0.49 ± 0.72	0.74 ± 1.10	≤0.001
FBG (mmol/L)	4.72 ± 0.73	4.77 ± 0.38	0.635	4.87 ± 0.49	4.92 ± 0.49	0.631	0.06 ± 0.66	0.05 ± 0.35	0.971
BUN (mmol/L)	4.53 ± 1.09	3.92 ± 0.82	0.016	3.90 ± 0.86	3.94 ± 0.82	0.900	−0.61 ± 1.30	0.04 ± 1.10	0.137
SCr (µmol/L)	55.59 ± 12.54	51.15 ± 10.51	0.005	51.25 ± 19.08	53.92 ± 13.66	0.584	−4.43 ± 8.06	5.00 (4.00∼15.0)	0.004
Che (KU/L)	10.39 ± 2.16	10.6 (9.7∼11.8)	0.136	9.97 ± 1.05	10.04 ± 1.14	0.627	0.39 ± 1.94	0.16 ± 1.13	0.707
LDH (U/L)	281.14 ± 43.03	250.23 ± 32.85	≤ 0.001	278.00 ± 53.16	269.73 ± 50.26	0.524	−31.21 ± 40.71	−8.27 ± 43.59	0.114
hsCRP (mg/L)	3.23 (1.79∼4.34)	0.92 (0.42∼1.21)	≤ 0.001	1.83 (0.79 ± 2.52)	2.26 (0.63∼3.91)	0.117	−1.93 (−2.47∼−0.97)	0.64 (−0.28∼1.99)	≤ 0.001