Research Article
Association of ANKRD55 Gene Polymorphism with HT: A Protective Factor for Disease Susceptibility
Table 3
Allele and genotype frequencies of the five loci in AITD, GD, HT, and controls.
| | Gene/SNP | Controls | AITD | value (OR, 95% CI) | GD | value (OR, 95% CI) | HT | value (OR, 95% CI) | | ANKRD55 | n (%) | n (%) | AITD vs. controls | n (%) | GD vs. controls | n (%) | HT vs. controls |
| | rs321776 | | C | 1168 (71.39) | 1561 (69.63) | 0.23 (1.09, 0.95–1.25) | 949 (68.47) | 0.08 (1.15, 0.98–1.34) | 612 (71.50) | 0.96 (0.99, 0.8–1.20) | | T | 468 (28.61) | 681 (30.37) | 437 (31.53) | 244 (28.50) | | TT | 62 (7.58) | 92 (8.21) | 0.44 | 67 (9.67) | 0.2 | 25 (5.84) | 0.35 | | TC | 344 (42.05) | 497 (44.33) | 303 (43.72) | 194 (45.33) | | CC | 412 (50.37) | 532 (47.46) | 323 (46.61) | 209 (48.83) |
| | rs191205 | | A | 1172 (71.55) | 1572 (69.99) | 0.29 (1.08, 0.94–1.24) | 961 (68.94) | 0.12 (1.13, 0.97–1.33) | 611 (71.71) | 0.93 (0.99, 0.83–1.19) | | G | 466 (28.45) | 674 (30.01) | 433 (31.06) | 241 (28.29) | | AA | 414 (50.55) | 540 (48.09) | 0.55 | 331 (47.49) | 0.24 | 209 (49.06) | 0.33 | | AG | 344 (42.00) | 492 (43.81) | 299 (42.90) | 193 (45.31) | | GG | 61 (7.45) | 91 (8.10) | 67 (9.61) | 24 (5.63) |
| | rs7731626 | | G | 1503 (91.65) | 2074 (91.85) | 0.82 (0.97, 0.77–1.23) | 1265 (90.62) | 0.32 (1.14, 0.88–1.46) | 809 (93.85) | 0.048 (0.72, 0.52–1.00) | | A | 137 (8.35) | 184 (8.15) | 131 (9.38) | 53 (6.15) | | AA | 5 (0.61) | 7 (0.62) | 0.97 | 4 (0.57) | 0.54 | 3 (0.70) | 0.08 | | AG | 127 (15.49) | 170 (15.06) | 123 (17.62) | 47 (10.90) | | GG | 688 (83.90) | 952 (84.32) | 571 (81.81) | 381 (88.40) |
| | rs415407 | | A | 1131 (69.39) | 1596 (71.57) | 0.14 (0.90, 0.78–1.04) | 975 (71.06) | 0.32 (0.92, 0.79–1.08) | 621 (72.37) | 0.12 (0.87, 0.72–1.04) | | C | 499 (30.61) | 634 (28.43) | 397 (28.94) | 237 (27.63) | | AA | 391 (47.98) | 565 (50.68) | 0.30 | 346 (50.44) | 0.60 | 219 (51.05) | 0.17 | | AC | 349 (42.82) | 466 (41.79) | 283 (41.25) | 183 (42.66) | | CC | 75 (9.20) | 84 (7.53) | 57 (8.31) | 27 (6.29) |
| | rs159572 | | C | 1073 (65.75) | 1491 (66.03) | 0.85 (0.99, 0.86–1.13) | 888 (63.61) | 0.22 (1.10, 0.95–1.28) | 603 (69.95) | 0.03 (0.82, 0.69–0.99) | | A | 599 (34.25) | 767 (33.97) | 508 (36.38) | 259 (30.05) | | AA | 94 (11.52) | 127 (11.25) | 0.98 | 85 (12.18) | 0.36 | 42 (9.75) | 0.08 | | AC | 371 (45.47) | 513 (45.44) | 338 (48.42) | 175 (40.60) | | CC | 351 (43.01) | 489 (43.31) | 275 (39.40) | 214 (49.65) |
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AITD, autoimmune thyroid diseases; GD, graves’ disease; HT, hashimoto’s thyroiditis. 95% CI, 95% confidence interval; OR, odds ratio.
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