Association of ANKRD55 Gene Polymorphism with HT: A Protective Factor for Disease Susceptibility
Table 4
Odds ratios (ORs) of the associations of five polymorphisms in the ANKRD55 gene with HT before and after adjusting for age and gender.
Comparison models
Unadjusted
Adjusted
OR (95% CI)
value
OR (95% CI)
value
rs321776
Allele model
0.99 (0.82–1.20)
0.96
0.99 (0.81–1.20)
0.88
Dominant model
1.06 (0.84–1.34)
0.61
1.06 (0.83–1.35)
0.64
Recessive model
0.76 (0.47–1.22)
0.25
0.72 (0.44–1.19)
0.19
Homozygous model
0.79 (0.49–1.30)
0.36
0.76 (0.45–1.27)
0.29
Additive model
1.11 (0.87–1.42)
0.39
1.12 (0.87–1.44)
0.40
rs191205
Allele model
0.99 (0.82–1.20)
0.93
0.99 (0.81–1.20)
0.89
Dominant model
1.06 (0.84–1.34)
0.62
1.06 (0.83–1.35)
0.64
Recessive model
0.74 (0.46–1.21)
0.22
0.72 (0.44–1.20)
0.20
Homozygous model
0.78 (0.47–1.29)
0.33
0.76 (0.45–1.28)
0.30
Additive model
1.11 (0.87–1.42)
0.39
1.11 (0.86–1.43)
0.41
rs7731626
Allele model
0.72 (0.52–1.00)
<0.05
0.70 (0.49–0.98)
0.04
Dominant model
0.68 (0.48–0.97)
0.03
0.65 (0.45–0.94)
0.02
Recessive model
1.14 (0.27–4.80)
0.86
1.67 (0.36–7.80)
0.52
Homozygous model
1.08 (0.26–4.56)
0.91
1.57 (0.34–7.38)
0.57
Additive model
0.67 (0.47–0.96)
0.03
0.63 (0.43–0.91)
0.01
rs415407
Allele model
0.86 (0.72–1.04)
0.11
0.90 (0.74–1.09)
0.28
Dominant model
0.88 (0.70–1.12)
0.30
0.92 (0.72–1.17)
0.49
Recessive model
0.66 (0.42–1.05)
0.07
0.74 (0.46–1.19)
0.20
Homozygous model
0.64 (0.40–1.03)
0.64
0.72 (0.44–1.18)
0.19
Additive model
0.94 (0.73–1.19)
0.60
0.96 (0.74–1.23)
0.73
rs159572
Allele model
0.83 (0.69–0.99)
0.03
0.80 (0.67–0.97)
0.02
Dominant model
0.77 (0.61–0.97)
0.03
0.73 (0.57–0.93)
0.01
Recessive model
0.83 (0.56–1.22)
0.34
0.83 (0.55–0.23)
0.34
Homozygous model
0.73 (0.49–1.09)
0.13
0.71 (0.47–1.08)
0.11
Additive model
0.77 (0.60–0.99)
0.04
0.73 (0.57–0.95)
0.02
Allele model = G vs. C; dominant model = (GG + GC) vs. CC; recessive model = GG vs. (GC + CC); homozygous model = GG vs. CC; additive model = GC vs. CC 95% CI, 95% confidence interval; OR, odds ratio.
