A Comparison of the Blood Glucose, Growth Hormone, and Cortisol Responses to Two Doses of Insulin (0.15 U/kg vs. 0.10 U/kg) in the Insulin Tolerance Test: A Single-Centre Audit of 174 Cases

Table 2

Glucose, cortisol, and growth hormone responses to the ITT.

	Standard dose 0.15 U/kg	Low dose 0.10 U/kg
Glucose (mmol/L)	n = 113	n = 61
Nadir mean ± SD (range)	1.07 ± 0.36 (0.30–2.20)	1.16 ± 0.40 (0.40–2.10)
Growth hormone (µg/L)	n = 112	n = 60
Adequate response (>3.0) n (%)	82 (73.2%)	45 (75.0%)
Mean ± SD (range)	13.3 ± 8.8 (3.1–44.9)	16.5 ± 12.4 (3.1–55.6)
Time point when >3	n (% of 82)	n (% of 45)
0 min.	6 (7%)	5 (11%)
30 min.	25 (30%)	14 (31%)
45 min.	63 (77%)	33 (73%)
60 min.	81 (99%)	43 (96%)
90 min.	82 (100%)	45 (100%)
120 min.	—	—
Inadequate response (≤3.0) n (%)	30 (26.8%)	15 (25.0%)
Mean ± SD (range)	1.1 ± 0.8 (0.1–2.8)	1.3 ± 1.0 (0.03–2.9)
Cortisol (nmol/L)	n = 106	n = 60
Adequate response (>450) n (%)	77 (72.6%)	32 (53.3%)
Mean ± SD (range)	560 ± 66 (456–799)	519 ± 61 (452–731)
Time point when >450	n (% of 77)	n (% of 32)
0 min.	3 (4%)	1 (3%)
30 min.	5 (6%)	2 (6%)
45 min.	36 (47%)	7 (22%)
60 min.	71 (92%)	26 (81%)
90 min.	77 (100%)	32 (100%)
120 min.	—	—
Borderline response (400–450) n (%)	10 (9.4%)	7 (11.7%)
Mean ± SD (range)	417 ± 27 (403–439)	424 ± 15 (409–440)
Inadequate response (<400) n (%)	19 (17.9%)	21 (35.0%)
Mean ± SD (range)	233 ± 133 (19–393)	284 ± 121 (7–397)

vs. standard, vs. standard.