Impact of Weight Reduction on Thyroid Function and Nonalcoholic Fatty Liver among Egyptian Adolescents with Obesity
Table 2
Comparison of clinical, laboratory, and radiological variables of the studied participants before and after weight reduction measures.
Variables
Before mean ± SD
After mean ± SD
valuea
BMI
32.05 ± 3.36
28.1 ± 2.77
<0.001a
BMI (z-score)
2.96 ± 0.52
2.34 ± 0.59
<0.001a
Obesity grades
Overweight
0 (0)
16 (26.2)
0.002b
Obese I
39 (63.9)
35 (57.4)
Obese II
22 (36.1)
10 (16.4)
Acanthosis nigricans
Absent
47 (77)
48 (78.7)
0.82b
Present
14 (23)
13 (21.3)
Blood pressure, n (%)
Normal
53 (86.8)
58 (95.1)
0.002b
Elevated
8 (13.2)
3 (4.9)
Systolic BP (mmHg)
107.52 ± 11.34
101.68 ± 9.71
0.008
Diastolic BP (mmHg)
62.59 ± 10.88
59.09 ± 10.36
0.001
Serum T4 (ug/dl)
11.0 ± 1.65
10.4 ± 1.59
0.009a
TSH (mU/L)
5.2 ± 2.86
3.9 ± 1.59
<0.001a
TSH, n (%)
Normal
32 (52.5)
49 (80.3)
0.011b
Elevated
29 (47.5)
12 (19.7)
HbA1c (%)
4.7 ± 0.37
4.5 ± 0.29
<0.001a
Lipid profile
Triglyceride (mg/dl)
136.4 ± 26.6
115.6 ± 18.4
<0.001a
Total cholesterol (mg/dl)
160.3 ± 20.1
145.3 ± 13.6
<0.001a
LDL (mg/dl)
113.5 ± 20.6
99.2 ± 14.7
<0.001a
HDL (mg/dl)
47.4 ± 4.9
47.3 ± 5.7
0.975a
ALT (IU/L)
41.8 ± 18.4
36.0 ± 10.2
<0.001a
US for the fatty liver, n (%)
Absent
42 (68.9)
45 (73.8)
0.54b
Present
19 (31.1)
16 (26.2)
a values are based on the paired t-test. Statistical significance at .b values are based on McNemar’s test. Statistical significance at . Bold values represent the significant improvement after weight reduction measures.
