The Relationships among Plasma Fetuin-B, Thyroid Autoimmunity, and Fertilization Rate In Vitro Fertilization and Embryo Transfer
Table 1
Baseline characteristics of subjects according to the status of thyroid antibodies.
Variables
TAI positive
TAI negative
value
(n = 120)
(n = 60)
Age (years)
31.43 ± 3.79
31.45 ± 4.32
0.979
BMI (kg/m2)
20.97 ± 1.63
21.07 ± 1.53
0.692
Infertility duration (years)
3.00 [2.00, 5.00]
3.00 [2.00, 5.00]
0.704
Infertility causes (%)
Female factor
88 (73.3%)
43 (71.7%)
Male factor
18 (15.0%)
11 (18.35%)
Combined factor
14 (11.7%)
6 (10.0%)
TSH (μIU/ml)
2.71 ± 1.00
2.37 ± 0.76
0.020
Free T3(pmol/l)
4.60 ± 0.58
4.69 ± 0.58
0.292
Free T4(pmol/l)
16.92 ± 2.70
16.82 ± 2.04
0.783
TPOAb (IU/ml)
280.57 ± 197.98
17.68 ± 6.96
<0.001
TgAb (IU/ml)
391.00 [189.55, 618.35]
20.30 [17.50, 24.10]
<0.001∗
LH (IU/L)
4.44 ± 1.30
4.65 ± 1.48
0.352
FSH (IU/L)
7.18 ± 1.60
6.90 ± 1.49
0.259
LH/FSH
0.64 ± 0.20
0.68 ± 0.19
0.148
Estradiol (pmol/L)
37.87 ± 10.09
39.85 ± 10.68
0.225
Prolactin (mIU/L)
17.68 ± 5.36
17.40 ± 4.93
0.731
Testosterone (nmol/L)
21.29 ± 8.08
21.67 ± 8.83
0.770
AMH (ng/ml)
3.19 ± 1.02
3.41 ± 1.19
0.198
Oocytes retrieved (N)
12.03 ± 3.70
11.93 ± 3.73
0.876
Available embryos(N)
5.49 ± 2.73
6.28 ± 2.81
0.071
Embryos transferred (N)
1.82 ± 0.53
1.82 ± 0.43
0.916
Low fertilization (%)
24 (20.0%)
4 (6.7%)
0.035#
Implantation (%)
71 (59.2%)
40 (66.7%)
0.416#
Pregnancy (%)
42 (35.0%)
27 (45.0%)
0.255#
Abortion (%)
23 (19.2%)
7 (11.7%)
0.289#
Live birth (%)
19 (15.8%)
8 (13.3%)
0.825#
Fetuin-B (ug/ml)
65.17 ± 18.54
76.43 ± 25.08
0.001
All data are expressed as mean ± SD, median [Q1-Q3], or proportion in %; Mann–Whitney U test was used in infertility duration and TgAb.#Chi-square or Fisher’s exact tests were used as appropriate for categorical variables. AMH, anti-Müllerian hormone; BMI, body mass index; Free T3, free triiodothyronine; Free T4, free thyroxine; FSH, follicle-stimulating hormone; LH, luteinizing hormone; TgAb, thyroglobulin antibody; TPOAb, thyroid peroxidase antibody; TSH, thyroid-stimulating hormone.
