Levothyroxine Timing during Ramadan: A Randomized Clinical Trial

Table 1

Demographic and clinical characteristics of the patients.

Factor	n (%)
Age
Mean (SD)	50 (14.8)
Median (IQR)	50 (39–63)
Minimum-maximum	18–80
Gender
Male	15 (19)
Female	64 (81)
Timing of thyroxine intake during Ramadan
30 minutes before iftar	29 (36.7)
4 hours after iftar	23 (29.1)
No specific advice	27 (34.2)
Duration of hypothyroidism (years)
Mean (SD)	6.4 (5.7)
Median (IQR)	4 (2–11)
Minimum-maximum	0.40–20
Average levothyroxine dose
Mean (SD)	112.2 (38.8)
Median (IQR)	107 (92–143)
Minimum-maximum	25–200
FT4 level before Ramadan (reference range 9.0–19.0 pmol/L)
Mean (SD)	14.1 (2.4)
Median (IQR)	13.7 (12.3–15.8)
Minimum-maximum	10–21.6
TSH level before Ramadan (reference range 0.35–4.94 mIU/L)
Mean (SD)	1.9 (1.8)
Median (IQR)	1.3 (0.5–3)
Minimum-maximum	0.01–6.7
Cause of hypothyroidism
Hashimoto	35 (44.3)
Postthyroidectomy	40 (50.6)
Postradioactive iodine	4 (5.1)
Other medications use
PPI	7 (8.9)
Calcium	16 (20.3)
No medications	56 (70.9)

SD, standard deviation; IQR, interquartile range; PPI, proton pump inhibitors.