Levothyroxine Timing during Ramadan: A Randomized Clinical Trial

Table 3

Multivariate repeated-measuresmixed-effects models for factors associated with changes in free T4 and TSH.

Factor	FT4		TSH
	β (95% CI)		β (95% CI)
Treatment initiation time
30 minutes before iftar	0.48 (−0.68, 1.63)	0.414	−0.41 (−1.40, 0.58)	0.413
4 hours after iftar	−0.20 (−1.45, 1.06)	0.754	−0.62 (−1.70, 0.457)	0.254
No specific advice	1		1
Cause of hypothyroidism
Hashimoto	2.92 (1.00, 5.15)	0.011	−0.21 (−2.13, 1.07)	0.824
Postthyroidectomy	3.72 (1.43–6.02)	0.002	−1.91 (−3.89, 0.06)	0.058
Postradioactive iodine	1		1
Other drug
Calcium	0.08 (−1.16, 1.31)	0.903	−0.95 (−2.01, 0.11)	0.079
PPI	−0.48 (−2.18, 1.22)	0.577	−1.26 (−2.73, 0.20)	0.09
No medications	1		1
Levothyroxin dose	0.03 (0.01, 0.41)	<0.0001	−0.002 (−0.01, 0.003)	0.157
Thyroxin compliance	0.18 (−0.03, 0.06)	0.414	−0.007 (−0.05, 0.03)	0.720