Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing’s Disease

Table 2

Spearman rank correlation of BMD and various variables in Cushing’s disease patients.

Variables	Z-score in lumbar spine		Z-score in femoral neck
	Coefficient	value	Coefficient	value
Age at diagnosis (years)	0.18801	0.0204	0.01793	0.827
Cushing duration (years)	−0.04584	0.5921	−0.15269	0.0738
BMI (kg/m^2)	0.12494	0.1385	0.33926	<0.0001
SBP (mm Hg)	−0.21575	0.0099	−0.08123	0.3383
DBP (mm Hg)	−0.32538	<0.0001	−0.12527	0.1388
ALT (mmol/L)	−0.17477	0.0426	0.05121	0.5568
AST (mmol/L)	−0.08974	0.3006	−0.00888	0.9189
Serum creatinine (mmol/L)	−0.36072	<0.0001	−0.19319	0.0248
UA (mmol/L)	−0.15829	0.0657	−0.1198	0.1663
HbA1c %	0.12066	0.1715	0.13429	0.1292
Chol (mmol/L)	−0.20205	0.0197	0.01576	0.8577
TG (mmol/L)	−0.16302	0.0608	−0.05957	0.4974
HDL (mmol/L)	−0.14705	0.0912	−0.05434	0.5361
LDL (mmol/L)	−0.15146	0.0818	0.05435	0.5359
IGF-1 index	0.35153	<0.0001	0.24418	0.0057
TSH (mIU/L)	0.11768	0.1807	0.01643	0.8528
Osteocalcin (ng/ml)	−0.07206	0.4739	−0.22744	0.0229
VD-OH25 (nmol/L)	0.11215	0.2871	0.00011	0.9992
PTH (pg/ml)	−0.17208	0.0763	−0.1419	0.1468
P1NP (ng/ml)	−0.11876	0.2972	−0.16851	0.1377
FT3 (nmol/L)	0.24117	0.0055	0.20487	0.0194
FT4 (nmol/L)	0.01175	0.894	0.11381	0.1973
T (ng/L)
Male	−0.2246	0.2601	−0.1484	0.4602
Female	−0.2700	0.0056	−0.2363	0.0162
Estradiol (ng/L)
Male	−0.1669	0.4252	0.0392	0.8524
Female	0.2361	0.0164	0.1020	0.3075
Normal menstruation in female N (%)	0.2267	0.0136	0.2393	0.0094
24h UF (nmol/24 h)	−0.13934	0.1006	0.02869	0.7375
F8 am (ug/dL)	−0.18998	0.031	−0.14753	0.0966
F24 pm (ug/dL)	−0.27273	0.0018	−0.1455	0.1013