CS27109, A Selective Thyroid Hormone Receptor-β Agonist Alleviates Metabolic-Associated Fatty Liver Disease in Murine Models

Figure 2

Chemical structure, THR-β activity, and PK properties of CS27109: (a) chemical structure of several oral and liver-targeted THR-β agonists, including KB-141, VK2809, MGL3196, and CS27109, (b) THR-α and THR-β activity for each compound were determined by a luciferase reporter gene assay, (c) hERG test of CS27109 was conducted by the QPatch HTX, (d) mouse, and (e) rat PK studies for CS27109 and MGL3196.

(a)

(b)

(c)

(d)

(e)