CS27109, A Selective Thyroid Hormone Receptor-<i>β</i> Agonist Alleviates Metabolic-Associated Fatty Liver Disease in Murine Models

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr class="thead"><td class="align_left">Compound</td><td class="align_center"> </td><td class="align_center">CS27109</td><td class="align_center">MGL3196</td><td class="align_center">T3</td></tr><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr><td class="align_left" rowspan="2">AC<sub>50</sub> (<i>μ</i>M)</td><td class="align_center"><i>β</i></td><td class="align_center">1.980</td><td class="align_center">21.32</td><td class="align_center">0.002780</td></tr><tr><td class="align_center"><i>α</i></td><td class="align_center">25.09</td><td class="align_center">192.1</td><td class="align_center">0.002481</td></tr><tr><td class="align_left" colspan="5"><hr/></td></tr><tr><td class="align_left">Selectivity (<i>α</i>/<i>β</i>)</td><td class="align_center"> </td><td class="align_center">12.67</td><td class="align_center">9.01</td><td class="align_center">0.89</td></tr><tr class="table-tr"><td colspan="5"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>AC<sub>50</sub> of THR-<i>α</i> and THR-<i>β</i> and selectivity of THR-<i>α</i>/THR-<i>β</i> for CS27109 and MGL3196.</div>

International Journal of Endocrinology

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Table 1

Table 1: CS27109, A Selective Thyroid Hormone Receptor-<i>β</i> Agonist Alleviates Metabolic-Associated Fatty Liver Disease in Murine Models 

International Journal of Endocrinology

CS27109, A Selective Thyroid Hormone Receptor-β Agonist Alleviates Metabolic-Associated Fatty Liver Disease in Murine Models

Table 1