CS27109, A Selective Thyroid Hormone Receptor-β Agonist Alleviates Metabolic-Associated Fatty Liver Disease in Murine Models

Table 3

Biochemical test in HFD-CHOL hamster model after 4-week drug intervention. and ^#represents normal vs. model and drugs vs. model, respectively. , , , and .

Groups	Normal	Model	MGL-3196	CS27109-L	CS27109-M	CS27109-H
AST (U/L)	98 ± 45	638 ± 323	752 ± 261	564 ± 317	582 ± 383	416 ± 158
ALT (U/L)	94 ± 58	278 ± 174	206 ± 47	226 ± 104	141 ± 133	127 ± 47^#
TG (mmol/L)	2.1 ± 1.1	26 ± 24	5.9 ± 5.6^#	32 ± 31	17 ± 26	11 ± 19
TC (mmol/L)	3.1 ± 0.72	37 ± 13	18 ± 6.3^###	29 ± 8.6	25 ± 7.4^#	19 ± 7.9^###
LDL-c (mmol/L)	1.3 ± 0.54	17 ± 6.1	8.6 ± 3.3^###	13 ± 4.3	12 ± 3.8^#	8.7 ± 4.1^###
HDL-c (mmol/L)	1.6 ± 0.45	3.6 ± 1.1	2.9 ± 0.36	2.6 ± 0.62^#	3.0 ± 0.52	2.6 ± 0.53^#