CS27109, A Selective Thyroid Hormone Receptor-β Agonist Alleviates Metabolic-Associated Fatty Liver Disease in Murine Models

Table 4

Biochemical, organ/body weight ratio, and liver TC and TG test in HFD SD rat model after 4-week drug intervention. and ^# represents normal vs. model and drugs vs. model, respectively. , , , , , , and . L/B (%) stands for liver/body weight ratio and H/B stands for heart/body weight ratio.

Groups	Normal	Model	MGL-3196	CS27109-L	CS27109-M	CS27109-H
AST (U/L)	103 ± 21	365 ± 212	185 ± 66^#	213 ± 78	218 ± 82	253 ± 131
ALT (U/L)	32 ± 6.8	166 ± 95	74 ± 24^##	85 ± 34^##	68 ± 24^##	89 ± 50^#
TG (mmol/L)	0.53 ± 0.34	0.82 ± 0.73	0.11 ± 0.03	0.19 ± 0.08^##	0.22 ± 0.06^##	0.20 ± 0.08^##
TC (mmol/L)	1.5 ± 0.20	20 ± 13	3.3 ± 1.3^####	4.4 ± 1.8^####	2.9 ± 0.98^####	2.3 ± 0.65^####
LDL-c (mmol/L)	0.28 ± 0.06	9.7 ± 6.1	1.1 ± 0.65^####	1.6 ± 0.74^####	0.84 ± 0.44^####	0.59 ± 0.32^####
HDL-c (mmol/L)	1.1 ± 0.13	1.2 ± 0.44	0.94 ± 0.26	0.78 ± 0.18^#	0.98 ± 0.32	1.0 ± 0.30
L/B (%)	2.8 ± 0.26	5.1 ± 0.75	3.7 ± 0.42^####	4.0 ± 0.52^###	4.1 ± 0.56^##	3.9 ± 0.54^###
H/B (%)	0.28 ± 0.02	0.24 ± 0.02	0.27 ± 0.02	0.27 ± 0.03	0.28 ± 0.02^#	0.27 ± 0.02
Liver TG (μmol/g)	0.75 ± 12	102 ± 36	113 ± 38	71 ± 28	54 ± 24^#	69 ± 21
Liver TC (μmol/g)	6.0 ± 0.76	13 ± 2.2	12 ± 1.7	11 ± 1.1	10 ± 0.74^##	10 ± 2.2^##