CS27109, A Selective Thyroid Hormone Receptor-β Agonist Alleviates Metabolic-Associated Fatty Liver Disease in Murine Models

Table 5

Biochemical and liver/body weight ratio test in WD + CCL4 model after 4-week drug intervention. and ^# represents normal vs. model and drugs vs. model, respectively. , , , , and . L/B (%) stands for liver/body weight ratio.

Groups	Normal	Model	MGL-3196	CS27109-L	CS27109-M	CS27109-H
AST (U/L)	116 ± 71	10245 ± 4955	2178 ± 769^###	13447 ± 6633	4804 ± 1121^#	3660 ± 1208^##
ALT (U/L)	54 ± 15	14003 ± 4205	4658 ± 1639^###	19162 ± 4012	10478 ± 2131^##	7832 ± 2422^###
TG (mmol/L)	0.91 ± 0.14	1.2 ± 0.34	1.0 ± 0.23	1.2 ± 0.34	1.2 ± 0.19	1.2 ± 0.18
TC (mmol/L)	3.0 ± 0.10	4.1 ± 0.97	1.9 ± 0.17^###	2.3 ± 0.40^###	2.2 ± 0.36^###	2.4 ± 0.48^###
LDL-c (mmol/L)	0.43 ± 0.04	1.1 ± 0.35	0.33 ± 0.05^###	0.40 ± 0.10^###	0.37 ± 0.07^###	0.39 ± 0.11^###
HDL-c (mmol/L)	2.0 ± 0.08	1.5 ± 0.25	1.2 ± 0.13^#	0.85 ± 0.24^###	0.94 ± 0.25^###	1.2 ± 0.31^#
CK (mmol/L)	334 ± 193	345 ± 268	197 ± 129	331 ± 386	201 ± 95	280 ± 147
L/B (%)	3.5 ± 0.27	3.5 ± 0.27	3.6 ± 0.58	3.3 ± 0.40	3.2 ± 0.68	3.2 ± 0.79