Effects of 18 Months of Growth Hormone Replacement Therapy on Bone Mineral Density in Patients with Adult Growth Hormone Deficiency: A Retrospective Study
Table 1
Baseline characteristics of all AGHD patients.
Characteristics
All (n = 68)
Males (n = 22)
Females (n = 46)
value
Age (years)
42.90 ± 11.52
43.55 ± 9.37
42.59 ± 12.51
0.751
Weight (kg)
60.22 ± 10.58
69.74 ± 9.68
55.67 ± 7.58
<0.001
Height (cm)
159.88 ± 9.18
168.86 ± 7.10
155.59 ± 6.60
<0.001
BMI (kg/m2)
23.43 ± 2.52
24.40 ± 2.27
22.96 ± 2.52
0.027
Grip strength (kg)
28.39 (21.08, 32.09)
39.28 (32.09, 44.43)
23.18 (20.65, 26.44)
<0.001
Waist circumference (cm)
83.47 ± 8.88
89.35 ± 7.05
80.65 ± 8.31
<0.001
Hip circumference (cm)
93.74 (90.35, 98.00)
96.64 (92.88, 99.43)
92.35 (88.15, 99.43)
0.019
WHR
0.89 (0.86, 0.93)
0.92 (0.89, 0.97)
0.87 (0.83, 0.90)
<0.001
SBP (mm Hg)
113.53 (106.25, 119.00)
118.09 (109.75, 126.50)
111.35 (106.00, 117.50)
0.011
DBP (mm Hg)
75.06 (69.25, 81.00)
79.00 (72.00, 85.00)
73.17 (67.00, 77.25)
0.016
FPG (mmol/L)
5.26 ± 0.44
5.35 ± 0.44
5.21 ± 0.45
0.253
FINS (uIU/ml)
7.33 (4.29, 9.06)
7.94 (2.86, 9.14)
7.03 (4.64, 9.18)
0.723
HbA1c (%)
5.58 (5.40, 5.70)
5.65 (5.50, 5.83)
5.54 (5.40, 5.63)
0.058
TSH (uIU/ml)
2.08 (1.00, 1.73)
2.43 (1.20, 2.78)
1.91 (0.89, 2.58)
0.345
LDL (mmol/L)
2.97 ± 0.91
3.06 ± 1.03
2.92 ± 0.86
0.570
HDL (mmol/L)
1.39 (1.14, 1.60)
1.32 (0.98, 1.51)
1.43 (1.18, 1.60)
0.230
TC (mmol/L)
4.65 ± 1.17
4.78 ± 1.13
4.59 ± 1.2
0.524
TG (mmol/L)
1.50 (0.81, 1.80)
1.45 (0.78, 1.90)
1.52 (0.83, 1.65)
0.704
ALT (U/L)
21.99 (13.00, 28.25)
24.59 (16.25, 31.75)
20.74 (11.75, 25.25)
0.113
AST (U/L)
21.07 (15.00, 26.75)
22.68 (15.00, 27.25)
20.30 (15.00, 22.25)
0.109
Peak GH (ng/ml)
2.11 (0.28, 3.67)
2.00 (0.15, 3.49)
2.15 (0.31, 3.82)
0.704
IGF-1 (ng/ml)
133.63 ± 68.12
137.66 ± 73.99
131.71 ± 65.90
0.739
Lumbar spine BMD (g/cm2)
0.860 ± 0.127
0.828 ± 0.108
0.870 ± 0.135
0.323
Total hip BMD (g/cm2)
0.820 ± 0.096
0.845 ± 0.101
0.808 ± 0.093
0.139
Lumbar spine T-score (SD)
−1.82 ± 1.21
−2.31 ± 0.99
−1.59 ± 1.25
0.022
Lumbar spine Z-score (SD)
−1.41 ± 1.18
−2.08 ± 1.05
−1.09 ± 1.10
0.001
Total hip T-score (SD)
−1.15 ± 0.73
−1.26 ± 0.69
−1.10 ± 0.76
0.413
Total hip Z-score (SD)
−0.82 ± 0.73
−1.02 ± 0.75
−0.73 ± 0.71
0.127
SBP, systolic blood pressure; DBP, diastolic blood pressure; TSH, thyroid stimulating hormone; LDL, low-density lipoprotein cholesterol; HDL, high-density lipoprotein cholesterol; TC, total cholesterol; TG, total glyceride; ALT, alanine aminotransferase; AST, aspartate aminotransferase. Data are expressed as the mean ± SD or M ( and ). males compared with females; males compared with females; males compared with females.
