Associations of Combined Exposure to Metabolic and Inflammatory Indicators with Thyroid Nodules in Adults: A Nested Case-Control Study

Table 2

Associations between metabolic/inflammatory indicators and thyroid nodules using conditional logistic regression.

Metabolic indicators	Adjusted models^a
	OR (95% CI)	value	value^b
TC
Q1	1	—	—
Q2	1.08 (0.90, 1.30)	0.413	0.707
Q3	1.07 (0.89, 1.29)	0.471	0.707
Q4	1.01 (0.84, 1.22)	0.883	0.883
P-trend	0.956
LDL
Q1	1	—	—
Q2	1.12 (0.92, 1.36)	0.244	0.453
Q3	1.11 (0.91, 1.34)	0.302	0.453
Q4	1.06 (0.87, 1.28)	0.583	0.583
P-trend	0.674
TG
Q1	1	—	—
Q2	0.99 (0.82, 1.20)	0.933	0.933
Q3	1.10 (0.91, 1.34)	0.307	0.461
Q4	1.15 (0.94, 1.40)	0.164	0.461
P-trend	0.102
HDL
Q1	1	—	—
Q2	0.83 (0.68, 1.00)	0.056	0.084
Q3	0.75 (0.61, 0.91)	0.005	0.015
Q4	0.87 (0.71, 1.06)	0.162	0.162
P-trend	0.188
FBG
Q1	1	—	—
Q2	1.10 (0.90, 1.33)	0.348	0.348
Q3	1.20 (1.00, 1.45)	0.056	0.084
Q4	1.30 (1.07, 1.58)	0.008	0.024
P-trend	0.005
UA
Q1	1	—	—
Q2	1.03 (0.85, 1.24)	0.795	0.795
Q3	1.10 (0.89, 1.36)	0.363	0.626
Q4	1.10 (0.88, 1.37)	0.417	0.626
P-trend	0.359
SBP
Q1	1	—	—
Q2	0.96 (0.79, 1.17)	0.692	0.865
Q3	0.98 (0.81, 1.19)	0.865	0.865
Q4	1.30 (1.08, 1.57)	0.006	0.018
P-trend	0.004
DBP
Q1	1	—	—
Q2	0.99 (0.81, 1.20)	0.916	0.916
Q3	1.09 (0.90, 1.31)	0.369	0.554
Q4	1.26 (1.04, 1.53)	0.016	0.048
P-trend	0.009
Inflammatory indicators	Adjusted models^a
	OR (95% CI)	value	value^b
WBC
Q1	1	—	—
Q2	1.03 (0.86, 1.25)	0.724	0.724
Q3	1.23 (1.03, 1.48)	0.026	0.044
Q4	1.23 (1.02, 1.48)	0.029	0.044
P-trend	0.095
M
Q1	1	—	—
Q2	1.01 (0.84, 1.20)	0.955	0.955
Q3	1.09 (0.89, 1.32)	0.406	0.609
Q4	1.20 (0.99, 1.44)	0.062	0.186
P-trend	0.057
L
Q1	1	—	—
Q2	1.16 (0.97, 1.39)	0.111	0.167
Q3	1.01 (0.83, 1.21)	0.957	0.957
Q4	1.19 (0.99, 1.43)	0.061	0.167
P-trend	0.625
B
Q1	1	—	—
Q2	0.95 (0.79, 1.14)	0.564	0.564
Q3	1.17 (0.97, 1.40)	0.104	0.312
Q4	1.08 (0.89, 1.30)	0.438	0.564
P-trend	0.256
E
Q1	1	—	—
Q2	1.07 (0.89, 1.30)	0.463	0.753
Q3	1.06 (0.87, 1.29)	0.547	0.753
Q4	0.97 (0.79, 1.18)	0.753	0.753
P-trend	0.311
N
Q1	1	—	—
Q2	1.04 (0.86, 1.26)	0.683	0.683
Q3	1.25 (1.04, 1.50)	0.020	0.030
Q4	1.28 (1.07, 1.55)	0.008	0.024
P-trend	0.040

TC: total cholesterol; LDL: low-density lipoprotein; TG: triglycerides; HDL: high-density lipoprotein; FBG: fasting blood glucose; UA: uric acid; SBP: systolic blood pressure; DBP: diastolic blood pressure; WBC: white blood cell; M: monocyte; B: basophil; E: eosinophil; L: lymphocyte; N: neutrophil. ^aAdjusting age, gender, diabetes, and hypertension. ^bFalse discovery rate (Benjamini and Hochberg). Bold values indicate statistical significance, P < 0.05.