Association between Glycosylated Hemoglobin and Serum Uric Acid: A US NHANES 2011–2020
Table 2
Association between Hb1Ac (%) and SUA (μmol/L).
Exposure
Model 1
Model 2
Model 3
β (95% CI) value
β (95% CI) value
β (95% CI) value
Hb1Ac (%)
2.89 (1.19, 4.60) 0.0009
−0.82 (−2.44, 0.80) 0.3196
−7.93 (−9.49, −6.37) <0.0001
Glycosylated hemoglobin categories
Q1 (2.8–5.2)
−29.20 (−49.64, −8.75) 0.0052
−16.77 (−34.34, 0.80) 0.0616
−14.82 (−31.13, 1.49) 0.0752
Q2 (5.2–5.5)
0.68 (−44.42, 45.79) 0.9763
−10.17 (−49.55, 29.21) 0.6128
−23.59 (−59.29, 12.11) 0.1954
Q3 (5.5–5.9)
25.63 (−5.31, 56.56) 0.1046
27.15 (−1.35, 55.66) 0.0620
3.38 (−23.20, 29.96) 0.8031
Q4 (5.9–17)
−9.87 (−12.33, −7.42) <0.0001
−9.42 (−11.79, −7.04) <0.0001
−11.79 (−14.08, −9.50) <0.0001
for trend
<0.0001
<0.0001
<0.0001
Subgroup analysis stratified by sex
Male
−3.07 (−5.17, −0.98) 0.0041
−3.75 (−5.94, −1.57) 0.0008
−10.38 (−12.51, −8.24) <0.0001
Female
7.43 (5.12, 9.74) <0.0001
2.76 (0.40, 5.13) 0.0219
−5.06 (−7.31, −2.81) <0.0001
Subgroup analysis stratified by age
≥20, <40
3.54 (−0.55, 7.63) 0.0897
2.46 (−0.96, 5.88) 0.1581
−6.55 (−9.81, −3.29) <0.0001
≥40, <60
−1.55 (−4.11, 1.01) 0.2355
−3.03 (−5.37, −0.69) 0.0112
−9.44 (−11.68, −7.20) <0.0001
≥60, <80
2.26 (−0.93, 5.44) 0.1650
1.51 (−1.56, 4.58) 0.3349
−6.77 (−9.84, −3.71) <0.0001
≥80
2.84 (−7.80, 13.47) 0.6013
1.71 (−9.07, 12.49) 0.7565
−4.79 (−15.98, 6.40) 0.4018
Subgroup analysis stratified by race
Mexican American
−2.23 (−6.34, 1.88) 0.2884
−5.63 (−9.45, −1.80) 0.0040
−10.58 (−14.24, −6.91) <0.0001
Other Hispanic
0.65 (−4.17, 5.47) 0.7912
−3.01 (−7.46, 1.44) 0.1850
−11.04 (−15.61, −6.47) <0.0001
Non-Hispanic White
7.19 (3.94, 10.43) <0.0001
2.05 (−1.06, 5.17) 0.1970
−9.38 (−12.39, −6.36) <0.0001
Non-Hispanic Black
2.99 (−0.13, 6.12) 0.0604
−0.41 (−3.30, 2.47) 0.7780
−5.95 (−8.70, −3.20) <0.0001
Other race/ethnicity
2.94 (−2.28, 8.16) 0.2705
0.54 (−4.43, 5.51) 0.8312
−6.67 (−11.64, −1.69) 0.0088
Model 1: no covariates were adjusted. Model 2: age, sex, and race were adjusted. Model 3: age, sex, race/ethnicity, education level, the ratio of family income to poverty, BMI, energy intake, protein intake, carbohydrate intake, dietary fiber intake, total fat intake, LDL-C, HDL-C, TG, TCHO, urine albumin, urine creatinine, albumin, creatinine ratio, SBP, DBP, heavy alcohol consumption, smoking status, and minutes sedentary activity were adjusted. In the subgroup analysis stratified by sex, age, and race/ethnicity, the model was not adjusted for sex, age, and race/ethnicity, respectively.
