International Journal of Endocrinology

Anaplastic Thyroid Carcinoma: Molecular Tools for Diagnosis and Therapy


Status
Published

1Dipartimento di Scienze Motorie e del Benessere, Via Medina 40, 80133 Naples, Italy

2Scuola di Medicina e Chirurgia, Università di Bologna, Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Anatomia Patologica, Ospedale Bellaria Via Altura 3, 40139 Bologna, Italy

3Institute of Molecular Biology and Genetics (IBGM),Valladolid University (Uva), Spanish Research Council (CSIC), Valladolid, Spain


Anaplastic Thyroid Carcinoma: Molecular Tools for Diagnosis and Therapy

Description

The incidence of thyroid cancer worldwide is increasing. Thyroid carcinomas derived from follicular epithelial cells include a broad spectrum of histotypes ranging from well-differentiated thyroid carcinoma, including papillary thyroid carcinoma (PTC) and follicular thyroid carcinoma (FTC), to poorly differentiated thyroid carcinoma and the rare anaplastic thyroid carcinoma (ATC). Whereas the prognosis of differentiated thyroid cancer is good, ATC is one of the most lethal human malignancies, 90% of patients die within six months of diagnosis. The sudden onset and explosive course of ATC necessitate immediate involvement by surgeons, radiation and medical oncologists, and palliative care teams. Target therapies for ATC are currently being evaluated in clinical trials. However, ATC is still resistant to all types of therapy, and disease prognosis has remained unchanged.

ATC may derive de novo or from preexisting papillary thyroid carcinoma or follicular thyroid carcinoma. Many patients do indeed have a history of preexisting well-differentiated thyroid carcinoma or nodular goiters. A small number of gene mutations have been identified in ATC, and there appears to be a progression in mutations acquired during dedifferentiation (e.g., RAS and BRAF). Other mutations found in ATC are in the TP53, -catenin, and PIK3CA genes. Thus, still little is known about the molecular events that lead from the highly curable differentiated tumors to ATCs.

Under this frame, we invite investigators to contribute with original articles and review articles addressing advances in molecular tools and therapy of ATC. Potential topics include, but are not limited to:

  • Molecular profiling of ATC
  • Predictive biomarkers of progression to ATC
  • Risk factors for ATC
  • Animal models of ATC
  • Histopathological tools for improved diagnosis of ATC
  • Genetic lesions in ATC
  • Epigenetics/methylome of ATC
  • Role of cancer stem cells in ATC
  • microRNAs in ATC
  • Targeted therapies of ATC

Before submission authors should carefully read over the journal’s Author Guidelines which are located at http://www.hindawi.com/journals/ije/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/ije/anapth/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 341725
  • - Editorial

Anaplastic Thyroid Carcinoma: Molecular Tools for Diagnosis and Therapy

Ginesa Garcia-Rostan | Giovanni Tallini | Giuliana Salvatore
  • Special Issue
  • - Volume 2015
  • - Article ID 439370
  • - Research Article

Anaplastic Thyroid Carcinoma: A ceRNA Analysis Pointed to a Crosstalk between SOX2, TP53, and microRNA Biogenesis

Walter Arancio | Valeria Carina | ... | Carla Giordano
  • Special Issue
  • - Volume 2015
  • - Article ID 978371
  • - Research Article

Synergy between HDAC and PARP Inhibitors on Proliferation of a Human Anaplastic Thyroid Cancer-Derived Cell Line

Federica Baldan | Catia Mio | ... | Giuseppe Damante
  • Special Issue
  • - Volume 2014
  • - Article ID 790834
  • - Review Article

Update on Anaplastic Thyroid Carcinoma: Morphological, Molecular, and Genetic Features of the Most Aggressive Thyroid Cancer

Moira Ragazzi | Alessia Ciarrocchi | ... | Simonetta Piana
  • Special Issue
  • - Volume 2014
  • - Article ID 743450
  • - Review Article

MicroRNA Deregulation in Anaplastic Thyroid Cancer Biology

Cesar Seigi Fuziwara | Edna Teruko Kimura
  • Special Issue
  • - Volume 2014
  • - Article ID 685396
  • - Review Article

Anaplastic Thyroid Carcinoma: Current Treatments and Potential New Therapeutic Options with Emphasis on TfR1/CD71

Rosalba Parenti | Lucia Salvatorelli | Gaetano Magro
  • Special Issue
  • - Volume 2014
  • - Article ID 816430
  • - Review Article

A New Aurora in Anaplastic Thyroid Cancer Therapy

Enke Baldini | Massimino D’Armiento | Salvatore Ulisse
  • Special Issue
  • - Volume 2014
  • - Article ID 240513
  • - Research Article

Age as a Prognostic Factor in Anaplastic Thyroid Cancer

Vladan Zivaljevic | Katarina Tausanovic | ... | Sandra Sipetic
  • Special Issue
  • - Volume 2014
  • - Article ID 815070
  • - Research Article

Risk Factors for Anaplastic Thyroid Cancer

V. Zivaljevic | N. Slijepcevic | ... | S. Sipetic
International Journal of Endocrinology
 Journal metrics
Acceptance rate35%
Submission to final decision48 days
Acceptance to publication46 days
CiteScore3.500
Impact Factor2.299
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