International Journal of Endocrinology

Male Hypogonadism and DHEA Deficiency: A Focus on Controversies in Replacement Therapy


Publishing date
01 Jan 2020
Status
Closed
Submission deadline
13 Sep 2019

Lead Editor

1Università Cattolica del Sacro Cuore, Rome, Italy

2University of Bari, Bari, Italy

This issue is now closed for submissions.
More articles will be published in the near future.

Male Hypogonadism and DHEA Deficiency: A Focus on Controversies in Replacement Therapy

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Male hypogonadism is a condition related to low total testosterone (T) levels and its free fractions (FT); according to gonadotropin levels it can be classified as primary (i.e., testicular failure) or secondary (due to alterations of the hypothalamic-pituitary axis). Clinical manifestations strictly depend on the age of onset. If symptoms begin at a very early age, at birth, or before puberty, it can easily be diagnosed as most of its symptoms are typical (female or intersexual internal and external genitalia, hypospadias, absent or incomplete pubertal development, eunuchoid body proportions, persistence of prepubertal external genitalia, cryptorchidism, etc.). By contrast, the late-onset form is characterized by symptoms and signs that are often unspecific and mimic natural male ageing (weakness, obesity, fatigue, low libido, depression, mild anaemia, sleep disturbances and osteoporosis, type 2 diabetes mellitus, etc.) and cannot be easily diagnosed. Due to the very important role of testosterone, beyond sexual differentiation, secondary sexual characteristics, and reproductive activity, many organs and systems can be affected, including bone, cardiovascular systems, adipose tissue, and the nervous system.

A number of questions are still open in this field, starting from the definition of “low T” itself; both the extremes of reproductive life (i.e., delayed puberty and ageing) raise questions to clinicians about diagnosis and treatment. Moreover, testosterone deficiency is related to a constellation of metabolic symptoms and increased cardiovascular risk. Oxidative stress can underlie both complications. Heart failure is accompanied by anabolic deficiency, but many controversies are present in literature about advantages or risk of replacement therapy.

Hypogonadism induced by androgen deprivation therapy in patients affected by carcinoma of the prostate is another field with unsolved questions.

On the other hand, another important anabolic hormone is DHEA, produced in a great amount by the adrenal gland and testes. The low levels of this hormone are also difficult to be defined; therefore “DHEA deficiency” has no precise borders. Trials with DHEA administration have been performed, especially in the field of heart failure, chronic obstructive pulmonary disease, and cognitive disorders, but its employment in common approach to bedside patients is still underestimated.

The aim of the present issue is to explore new ideas about the physiopathological and clinical aspects of hypogonadism and DHEA deficiency, with a focus on controversies in replacement therapy. Review articles are accepted, but we would also encourage original papers.

Potential topics include but are not limited to the following:

  • Controversies about the definition of hypogonadism and indication to replacement therapy
  • Oxidative stress in hypogonadism and effects of testosterone administration
  • Metabolic effects of androgen administration
  • Bone turnover in hypogonadism
  • Hypogonadism and prostate cancer; effects of androgen deprivation therapy
  • Functional hypogonadism: medical alternatives to testosterone replacement therapy?
  • Hypogonadism and cardiovascular disease: to treat or not to treat?
  • DHEAS deficiency in males and its clinical application

Articles

  • Special Issue
  • - Volume 2020
  • - Article ID 1942126
  • - Research Article

Increased DHEAS and Decreased Total Testosterone Serum Levels in a Subset of Men with Early-Onset Androgenetic Alopecia: Does a Male PCOS-Equivalent Exist?

Rossella Cannarella | Rosita A. Condorelli | ... | Aldo E. Calogero
  • Special Issue
  • - Volume 2020
  • - Article ID 9649838
  • - Review Article

Is There Room for SERMs or SARMs as Alternative Therapies for Adult Male Hypogonadism?

Vito A. Giagulli | Andrea Silvestrini | ... | Antonio Mancini
  • Special Issue
  • - Volume 2020
  • - Article ID 5798146
  • - Research Article

Anabolic Hormone Deficiencies in Heart Failure with Reduced or Preserved Ejection Fraction and Correlation with Plasma Total Antioxidant Capacity

Antonio Mancini | Angela Maria Rita Fuvuzzi | ... | Antonio Cittadini
  • Special Issue
  • - Volume 2019
  • - Article ID 6743489
  • - Research Article

Gonadotropin-Induced Spermatogenesis in CHH Patients with Cryptorchidism

Zhaoxiang Liu | Jiangfeng Mao | ... | Xueyan Wu
  • Special Issue
  • - Volume 2019
  • - Article ID 7546385
  • - Research Article

Metabolic Effects of Testosterone Hormone Therapy in Normal and Orchiectomized Male Rats: From Indirect Calorimetry to Lipolytic Enzymes

Mahmoud Mustafa Ali Abulmeaty | Ali Madi Almajwal | ... | Suhail Razak
  • Special Issue
  • - Volume 2019
  • - Article ID 6718761
  • - Research Article

Causes and Metabolic Consequences of Gynecomastia in Adult Patients

Ralitsa Robeva | Atanaska Elenkova | Sabina Zacharieva
  • Special Issue
  • - Volume 2019
  • - Article ID 1041760
  • - Research Article

Effects of Osteocalcin on Synthesis of Testosterone and INSL3 during Adult Leydig Cell Differentiation

Gulfidan Coskun | Leman Sencar | ... | Sait Polat
International Journal of Endocrinology
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