International Journal of Endocrinology

The Bone-Cardiovascular Axis: Mechanisms and Clinical Relevance


Status
Published

1Medical University of Graz, Graz, Austria

2University of Udine, Udine, Italy

3VU University, Amsterdam, Netherlands

4University of Bern, Bern, Switzerland


The Bone-Cardiovascular Axis: Mechanisms and Clinical Relevance

Description

Bone disease and cardiovascular disease often occur in concurrence and globally account for high morbidity and mortality. Rapidly growing evidence points towards mechanistic conjunctions between bone and the cardiovascular system. Bone is increasingly regarded as an endocrine organ that is closely interweaved with the cardiovascular system: bone metabolism is regulated by hemodynamic load and endothelial cells; vice versa, peptides secreted from bone cells are systemically active and affect cardiovascular risk factors, particularly atherosclerosis and arterial hypertension, and alter cardiac structure and function. However, exact and further mechanisms are only partially explained and evidence on the clinical relevance is inconclusive.

We invite authors to contribute original clinical research articles to extend existing knowledge on the bone-cardiovascular axis and its clinical relevance. We also encourage authors to submit review articles.

Potential topics include but are not limited to the following:

  • Interaction of bone-derived peptides (osteocalcin, FGF-23, etc.) with cardiomyocytes, vascular smooth muscle cells, endothelial cells, or other cardiovascular tissues
  • Molecular pathways in bone-cardiovascular axes
  • Epidemiological studies to investigate cardiovascular parameters as determinants of bone pathologies (e.g., osteoporosis, fractures, and altered bone metabolism)
  • Epidemiological studies in patients with disease phenotypes predisposing to bone and cardiovascular diseases (e.g., with primary hyperparathyroidism, primary aldosteronism, vitamin D deficiency, heart failure, and kidney disease)
  • Longitudinal epidemiological studies investigating associations between bone and cardiovascular disease
  • Interventional studies elucidating the bone-cardiovascular axis
  • Studies with drugs modulating (or possibly modulating) both bone and cardiovascular system

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 9689106
  • - Editorial

The Bone-Cardiovascular Axis: Mechanisms and Clinical Relevance

Nicolas Verheyen | Martin R. Grübler | ... | Adriana J. van Ballegooijen
  • Special Issue
  • - Volume 2017
  • - Article ID 1659071
  • - Research Article

A New Murine Model of Chronic Kidney Disease-Mineral and Bone Disorder

Bianca Frauscher | Katharina Artinger | ... | Kathrin Eller
  • Special Issue
  • - Volume 2017
  • - Article ID 4397028
  • - Review Article

Salt, Aldosterone, and Parathyroid Hormone: What Is the Relevance for Organ Damage?

Cristiana Catena | Gian Luca Colussi | ... | Leonardo A. Sechi
  • Special Issue
  • - Volume 2017
  • - Article ID 7454376
  • - Review Article

The Synergistic Interplay between Vitamins D and K for Bone and Cardiovascular Health: A Narrative Review

Adriana J. van Ballegooijen | Stefan Pilz | ... | Nicolas Verheyen
  • Special Issue
  • - Volume 2017
  • - Article ID 3206240
  • - Review Article

The Biphasic Effect of Vitamin D on the Musculoskeletal and Cardiovascular System

Armin Zittermann
  • Special Issue
  • - Volume 2017
  • - Article ID 3946569
  • - Research Article

The Association between Bone Quality and Atherosclerosis: Results from Two Large Population-Based Studies

V. Lange | M. Dörr | ... | A. Hannemann
  • Special Issue
  • - Volume 2017
  • - Article ID 4138783
  • - Clinical Study

Angiotensin-Converting Enzyme Inhibition and Parathyroid Hormone Secretion

Sarah Zaheer | Jenifer M. Brown | ... | Anand Vaidya
International Journal of Endocrinology
 Journal metrics
Acceptance rate35%
Submission to final decision48 days
Acceptance to publication46 days
CiteScore3.500
Impact Factor2.299
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