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Eicosanoids and Other Fatty Acid Metabolites in Female Reproduction: From Physiology to Clinical Practice

Call for Papers

Polyunsaturated fatty acids are important for cell metabolism and are known to exert a broad range of effects on mammalian reproductive function. They are precursors of a large family of signaling molecules, such as eicosanoids, involved in intracellular communications. Eicosanoids are the cyclooxygenase (COX) and lipooxygenase metabolites of arachidonic acid (AA) and constitute prostaglandins (PGs), leukotrienes (LT), and prostacyclins. Eicosanoids exert an autocrine or paracrine function by binding to specific G-protein-coupled receptors (GPCRs) to activate intracellular signaling and gene transcription. Eicosanoids are involved in the processes ranging from ovulation to parturition and also in reproductive pathologies such as preeclampsia. The importance of eicosanoids in reproduction is underlined by their role in activation of proteolytic enzymes during ovulation and parturition and their role in luteal regression and steroidogenesis and in immune modulation and increase of local blood flow and vascular permeability during implantation and dysregulated PG signaling during preeclampsia, preterm delivery, and endometriosis.

In this special issue, we hope to publish research articles giving new insights into understanding physiopathological role and mechanism by which each eicosanoid can preferentially recognize one or more receptors to act in reproductive function (from ovulation to parturition), aiming to provide a comprehensive update on the studies in this area.

We invite you to submit an original research article, review, and clinical studies to be considered for the special issue.

Potential topics include but are not limited to the following:

  • Fatty acid signaling in female reproduction
  • Eicosanoids and others fatty acid metabolites effects on cell biology, especially on different cell death modalities and cell-to-cell communication
  • Roles of eicosanoids in regulation of the central reproductive processes
  • Eicosanoids in folliculogenesis, ovulation, corpus luteum formation, ovarian steroidogenesis, and luteal regression
  • Prostanoids, leukotrienes, and PUFAs in gamete functions, early embryo development, and implantation including angiogenesis, placenta function, and parturition
  • Physiopathological roles of eicosanoids in endometrium
  • Modulatory effects of eicosanoids and other fatty acid metabolites on immune system
  • Eicosanoids in complex procedures of fetal growth and development
  • Cytokine-prostaglandin interactions in biology and pathology of reproduction
  • Prostaglandins and leukotrienes in reproductive disorders such as preeclampsia, endometritis, and endometriosis
  • Eicosanoids and other fatty acid metabolites and carcinogenesis in the reproductive tract

Authors can submit their manuscripts through the Manuscript Tracking System at

Submission DeadlineFriday, 24 November 2017
Publication DateApril 2018

Papers are published upon acceptance, regardless of the Special Issue publication date.

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