International Journal of Endocrinology

Circulating Noncoding RNAs as Candidate Biomarkers of Endocrine and Metabolic Disease


Status
Published

1University of Siena, Siena, Italy

2University of Lausanne, Lausanne, Switzerland

3Imperial College London-MRC London Institute of Medical Sciences, London, UK


Circulating Noncoding RNAs as Candidate Biomarkers of Endocrine and Metabolic Disease

Description

Noncoding RNAs are a newly discovered class of RNA molecules which regulate gene expression through different modes of action. Their discovery opened a new concept of posttranscriptional gene expression regulation by shedding light on the complexity of networks controlling different cellular processes. Indeed, noncoding RNAs regulate many biological processes and their dysregulation could strongly contribute to the pathogenesis of several diseases, including endocrine and metabolic diseases. Furthermore, some classes of noncoding RNAs (e.g., microRNAs, lncRNAs, and circRNAs) can be secreted by cells and detected in many biological fluids including serum or plasma, thus representing novel candidate biomarkers of metabolic/endocrine disease status. Additionally, it has been demonstrated that circulating noncoding RNAs may contribute to an unprecedented mode of cell-to-cell communication, thus highlighting their role as “new hormones.”

Several studies have been conducted to elucidate the physiological role of noncoding RNAs in the regulation of metabolism or in the modulation of endocrine cell functions, among others to characterize their circulating expression fingerprint which could be used for prediction, diagnosis, or prognosis/staging of the diseases. However, the exact circulating expression profile of noncoding RNAs in several metabolic diseases as well as modes of transport has not yet been fully addressed. Moreover, the presence of several discordant studies in the field illustrates the need to critically review technical approaches and preanalytical variables as well as to establish common objectives to pave the way for the identification of new metabolic/endocrine biomarkers.

Authors are invited to submit original research as well as review articles in areas of circulating noncoding RNAs in endocrine and metabolic diseases. Original researches on blood circulating RNAs as potential biomarkers of metabolic diseases are especially welcome as well as review articles with a main focus on the description of the state-of-the-art circulating noncoding RNAs and specific endocrine/metabolic diseases or on technical approaches to the measurement of circulating RNAs.

Potential topics include but are not limited to the following:

  • Circulating noncoding RNAs in endocrine and metabolic diseases
  • Noncoding RNAs secretion and endocrine cell-to-cell communication
  • New technical approaches for the detection of circulating noncoding RNAs in metabolic diseases

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 9514927
  • - Editorial

Circulating Noncoding RNAs as Candidate Biomarkers of Endocrine and Metabolic Diseases

Guido Sebastiani | Claudiane Guay | Mathieu Latreille
  • Special Issue
  • - Volume 2018
  • - Article ID 2342860
  • - Review Article

The Potential Role of miRNAs as New Biomarkers for Osteoporosis

Maria Materozzi | Daniela Merlotti | ... | Simone Bianciardi
  • Special Issue
  • - Volume 2018
  • - Article ID 6380463
  • - Review Article

Circulating MicroRNAs as Biomarkers of Gestational Diabetes Mellitus: Updates and Perspectives

Elisa Guarino | Chiara Delli Poggi | ... | Francesco Dotta
  • Special Issue
  • - Volume 2018
  • - Article ID 6872635
  • - Research Article

Circulating MicroRNAs in Elderly Type 2 Diabetic Patients

Giuseppina Catanzaro | Zein Mersini Besharat | ... | Elisabetta Ferretti
  • Special Issue
  • - Volume 2018
  • - Article ID 4302096
  • - Review Article

Noncoding RNAs Carried by Extracellular Vesicles in Endocrine Diseases

Margherita A. C. Pomatto | Chiara Gai | ... | Giovanni Camussi
  • Special Issue
  • - Volume 2018
  • - Article ID 7351902
  • - Research Article

Elevated and Correlated Expressions of miR-24, miR-30d, miR-146a, and SFRP-4 in Human Abdominal Adipose Tissue Play a Role in Adiposity and Insulin Resistance

Yury O. Nunez Lopez | Gabriella Garufi | ... | Attila A. Seyhan
  • Special Issue
  • - Volume 2018
  • - Article ID 6890501
  • - Review Article

MicroRNA and Microvascular Complications of Diabetes

F. Barutta | S. Bellini | ... | G. Gruden
International Journal of Endocrinology
 Journal metrics
Acceptance rate35%
Submission to final decision48 days
Acceptance to publication46 days
CiteScore3.500
Impact Factor2.299
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