International Journal of Endocrinology

Graves’ Orbitopathy


Status
Published

Lead Editor

1Kurume University, Kurume, Japan

2The University of Sydney, Sydney, Australia

3Gutenberg University, Mainz, Germany

4Aichi Medical University, Nagakute, Japan


Graves’ Orbitopathy

Description

Graves’ orbitopathy (GO) is an autoimmune disorder of the orbit that is closely associated with autoimmune thyroid diseases (AITD). Although the primary autoantigen(s) and precise mechanisms underlying the association between GO and AITD remain unclear, TSH receptors are thought to be the primary target of autoimmune reactions in GO patients.

We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the molecular pathology and mechanisms for the development of GO. Significant progress has been made in research on genetics, epigenetics, and animal models of GO. We also invite articles describing the new insights on clinical features, diagnosis, and managements of GO, including molecular target therapy using small molecules.

Potential topics include, but are not limited to:

  • Pathogenesis of GO: role of TSH receptor and IGF-1R antibodies; role of fibrocytes; animal models
  • Advances in genetics and epigenetics of GO
  • Clinical assessment and diagnosis of GO: identifying biomarkers; orbital imaging
  • Management of GO: medical therapy; radiotherapy; orbital decompression and rehabilitative surgery; small molecule targeted therapy
  • Translational topic between autoimmune thyroid diseases and GO

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 634234
  • - Editorial

Graves’ Orbitopathy

Yuji Hiromatsu | Jack R. Wall | ... | Hirohiko Kakizaki
  • Special Issue
  • - Volume 2015
  • - Article ID 285698
  • - Clinical Study

Efficacy of Subantimicrobial Dose Doxycycline for Moderate-to-Severe and Active Graves’ Orbitopathy

Miaoli Lin | Yuxiang Mao | ... | Dan Liang
  • Special Issue
  • - Volume 2015
  • - Article ID 860849
  • - Clinical Study

Results after En Bloc Lateral Wall Decompression Surgery with Orbital Fat Resection in 111 Patients with Graves’ Orbitopathy

Nicole Fichter | Rudolf F. Guthoff
  • Special Issue
  • - Volume 2015
  • - Article ID 703671
  • - Research Article

Predictors of the Dose-Effect Relationship regarding Unilateral Inferior Rectus Muscle Recession in Patients with Thyroid Eye Disease

Yasuhiro Takahashi | Hirohiko Kakizaki
  • Special Issue
  • - Volume 2015
  • - Article ID 835979
  • - Clinical Study

Liver Dysfunction Associated with Intravenous Methylprednisolone Pulse Therapy in Patients with Graves’ Orbitopathy

Hiroyuki Eguchi | Junichi Tani | ... | Yuji Hiromatsu
  • Special Issue
  • - Volume 2015
  • - Article ID 678194
  • - Research Article

Thyroid Stimulating but Not Blocking Autoantibodies Are Highly Prevalent in Severe and Active Thyroid-Associated Orbitopathy: A Prospective Study

E. Kampmann | T. Diana | ... | G. J. Kahaly
International Journal of Endocrinology
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Acceptance rate21%
Submission to final decision82 days
Acceptance to publication19 days
CiteScore4.000
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Impact Factor3.257
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