International Journal of Endocrinology

Nonalcoholic Fatty Liver Disease: Its Mechanisms and Complications


Publishing date
28 Jun 2013
Status
Published
Submission deadline
08 Feb 2013

Lead Editor

1Department of Physiology, University of Lausanne, Rue du Bugnon 7, 1005 Lausanne, Switzerland

2Départment Endocrinologie Metabolisme et Cancer, Institut Cochin, INSERM, U567, 22 Rue Méchain, 75014 Paris, France

3KineMed Inc., 5980 Horton Street, Emeryville, CA 94608, USA

4Biozentrum, University of Basel, Klingelbergstraße 70, 4056 Basel, Switzerland

5Section of Islet Cell and Regenerative Medicine, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA

6Center for Integrative Genomics, University of Lausanne, Genopode, 1010 Lausanne, Switzerland


Nonalcoholic Fatty Liver Disease: Its Mechanisms and Complications

Description

Nonalcoholic fatty liver disease (NAFLD) is a hall mark of metabolic syndromes. The disease progresses from a simple fat accumulation (hepatic steatosis) to liver inflammation (nonalcoholic steatohepatitis, called NASH) and to liver cirrhosis. The prevalence of NAFLD in general population is around 20%, and it increases up to 90% in the obese population. Because of the concomitant metabolic disorders such as obesity and diabetes in NAFLD patients, the mechanisms by which the hepatic steatosis induces insulin resistance and NASH have still been unclear.

We invite investigators to contribute original research articles as well as review articles that will contribute to uncover mechanisms of how the liver deals with metabolic stress and develops hepatic steatosis and NASH. We encourage researchers to submit papers describing molecular pathologies underlying insulin resistance during NAFLD, clinical significance in NAFLD patients, and possible diagnosis and treatment against NAFLD.

We are particularly interested in articles describing new molecular pathways leading insulin resistance and/or inflammation in the liver, advances in molecular genetics and molecular diagnostics using animal models and siRNA techniques, evaluations of outcomes from treatment trials, new insight into cirrhosis development, and viral and nonviral gene therapy strategies. Potential topics include, but not limited to:

  • Recent advances in understanding insulin resistance in NAFLD
  • Role of inflammation in the development of NAFLD
  • Role of hepatitis C virus in the development of NAFLD
  • Recent advances in NAFLD treatment
  • Population study and clinical trials in NAFLD
  • Recent advances in drug discovery for NAFLD

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/ije/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/ije/nafld/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2013
  • - Article ID 969748
  • - Editorial

Nonalcoholic Fatty Liver Disease: Its Mechanisms and Complications

Abdelfattah El Ouaamari | Kaori Minehira
  • Special Issue
  • - Volume 2013
  • - Article ID 751854
  • - Research Article

Mechanism of the Inhibitory Effects of Eucommia ulmoides Oliv. Cortex Extracts (EUCE) in the CCl4-Induced Acute Liver Lipid Accumulation in Rats

Chang-Feng Jin | Bo Li | ... | Han-Jung Chae
  • Special Issue
  • - Volume 2013
  • - Article ID 585876
  • - Review Article

Increasing Whole Grain Intake as Part of Prevention and Treatment of Nonalcoholic Fatty Liver Disease

Alastair B. Ross | Jean-Philippe Godin | ... | John P. Kirwan
  • Special Issue
  • - Volume 2013
  • - Article ID 428542
  • - Clinical Study

Hepatic Steatosis, Carbohydrate Intake, and Food Quotient in Patients with NAFLD

Concepcion Gonzalez | Victor de Ledinghen | ... | Vincent Rigalleau
  • Special Issue
  • - Volume 2013
  • - Article ID 870487
  • - Research Article

Intrahepatic Lipid Content and Insulin Resistance Are More Strongly Associated with Impaired NEFA Suppression after Oral Glucose Loading Than with Fasting NEFA Levels in Healthy Older Individuals

Francis M. Finucane | Stephen J. Sharp | ... | Nicholas J. Wareham
  • Special Issue
  • - Volume 2013
  • - Article ID 972962
  • - Research Article

Major Histocompatibility Class II Pathway Is Not Required for the Development of Nonalcoholic Fatty Liver Disease in Mice

Gilles Willemin | Catherine Roger | ... | Kaori Minehira
  • Special Issue
  • - Volume 2013
  • - Article ID 678159
  • - Review Article

Obesity and Inflammation: Epidemiology, Risk Factors, and Markers of Inflammation

Heriberto Rodríguez-Hernández | Luis E. Simental-Mendía | ... | Miguel A. Reyes-Romero
  • Special Issue
  • - Volume 2013
  • - Article ID 124958
  • - Research Article

Independent Association between Nonalcoholic Fatty Liver Disease and Cardiovascular Disease: A Systematic Review and Meta-Analysis

Hongyun Lu | Hong Liu | ... | Liao Sun
  • Special Issue
  • - Volume 2013
  • - Article ID 381014
  • - Research Article

Hepatic Steatosis and Thyroid Function Tests in Overweight and Obese Children

L. Pacifico | E. Bonci | ... | C. Chiesa
International Journal of Endocrinology
 Journal metrics
Acceptance rate35%
Submission to final decision48 days
Acceptance to publication46 days
CiteScore3.500
Impact Factor2.299
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