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International Journal of Electrochemistry
Volume 2011, Article ID 373498, 8 pages
Research Article

Single-Walled-Carbon-Nanotube-Modified Pyrolytic Graphite Electrode Used as a Simple Sensor for the Determination of Salbutamol in Urine

Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247667, India

Received 2 December 2010; Accepted 23 December 2010

Academic Editor: Bengi Uslu

Copyright © 2011 Rajendra N. Goyal et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A fast and sensitive voltammetric method has been proposed for the determination of salbutamol at single-walled-carbon-nanotube-modified edge-plane pyrolytic graphite electrode (SWNT/EPPGE) in human urine. The electrochemical response of salbutamol was determined by square wave voltammetry (SWV) in phosphate buffer solution (PBS) at physiological pH 7.2. The modified electrode showed improved voltammetric response towards the oxidation of salbutamol, and a well-defined anodic peak was observed at ~600 mV with enhanced peak current in comparison to the bare electrode. Linear calibration plot using SWNT/EPPGE was obtained in the concentration range of 50 to 2500 ngml-1 with sensitivity and detection limit of 2.15 nA/ngml-1 and 4.31 ngml-1, respectively. The developed method has been successfully applied for the determination of salbutamol in commercial preparations and human body fluids. Fast analysis of salbutamol in human urine makes the proposed method of great interest for doping control purposes at the site of competitive games.