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International Journal of Electrochemistry
Volume 2011 (2011), Article ID 452629, 6 pages
http://dx.doi.org/10.4061/2011/452629
Research Article

Development of a Method for a Sensitive Simultaneous Determination of Dopamine and Paracetamol in Biological Samples and Pharmaceutical Preparations

1Department of Chemistry, Arak University, Arak, P.O. Box 38156-879, Iran
2Research Center for Nanotechnology, Arak University, P.O. Box 38156-879, Iran
3Department of Chemistry, Islamic Azad University, Shoushtar Branch, Shoushtar, Iran

Received 14 March 2011; Accepted 3 May 2011

Academic Editor: Shane Peper

Copyright © 2011 Ali Babaei et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A chemically modified electrode is constructed based on multiwalled carbon nanotube—modified glassy carbon electrode (MWCNTs/GCE). The measurements were carried out by application of differential pulse voltammetry (DPV), cyclic voltammetry (CV), and chronoamperometry (CA) methods. Application of DPV method showed wide linear range of DA from 1 μM to 540 μM and a detection limit of 0.098 μM (S/N=3). The linear range of PAR of 3 μM to 300 μM and a detection limit of 0.15 μM, were obtained. The modified electrode showed electrochemical responses with high sensitivity, high selectivity, and excellent stability for DA and PAR determination at optimal conditions, which makes it a suitable sensor for simultaneous submicromolar detection of DA and PAR in solutions. The analytical performance of this sensor has been evaluated for detection of DA and PAR in human serum, human urine, and pharmaceutical preparation with satisfactory results.