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International Journal of Electrochemistry
Volume 2011, Article ID 603135, 11 pages
Research Article

Electrochemical Determination of Dopamine on a Glassy Carbon Electrode Modified by Using Nanostructure Ruthenium Oxide Hexacyanoferrate/Ruthenium Hexacyanoferrate Thin Film

Department of Chemistry, University of Isfahan, Isfahan 81746-73441, Iran

Received 12 February 2011; Revised 5 May 2011; Accepted 5 May 2011

Academic Editor: Kenneth I. Ozoemena

Copyright © 2011 Reza Karimi Shervedani and Hossein Ali Alinajafi-Najafabadi. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Application of mixed ruthenium oxide hexacyanoferrate/ruthenium hexacyanoferrate glassy carbon electrode for electrochemical determination of dopamine (DA) is described for the first time. The overlapped voltammetric oxidation potentials of ascorbic acid (AA) and DA are separated and shifted to more facile direction, +170 and +320 mV versus Ag/AgCl, respectively. Voltammetric response of the electrode toward the DA showed a dynamic calibration curve with two linear parts, from 0.50 to 10.00 μM and 25.00 to 550.00 μM DA, and a detection limit of 0.195 μM. The sensitivity (0.2917 μA/μM) and detection limit ( μMDA) of this electrode are 21 times higher and 11.5 times lower than those found in our previous paper. The sensor response of 9.95 μMDA was not affected by 5.0 mM of glucose, 4.5 mM of fructose, 0.58 mM of sucrose, 0.28 mM of cystine, 0.25 mM of ascorbic acid, 79.60 μM of cysteine, and 49.70 μM of uric acid and urea. The fabricated sensor was successfully tested for determination of DA in injection medicine and human blood plasma samples.