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International Journal of Electrochemistry
Volume 2011 (2011), Article ID 864358, 6 pages
Research Article

Voltammetric Determination of Captopril Using Chlorpromazine as a Homogeneous Mediator

Department of Chemistry, Razi University, Bagh Abrisham, Kermanshah 67149-67346, Iran

Received 6 August 2011; Accepted 22 August 2011

Academic Editor: Jay D. Wadhawan

Copyright © 2011 Hossein Bahramipur and Fahimeh Jalali. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Chlorpromazine was used as a homogeneous electrocatalyst in the oxidation of captopril. The anodic peak current of chlorpromazine was increased substantially in the presence of low concentrations of captopril (pH 4). Cyclic voltammetry and chronoamperometry were used to study the kinetics of the catalytic electron transfer reaction. The values of electron transfer coefficient ( ๐›ผ ) and catalytic rate constant ( ๐‘˜ c a t ) were estimated to be 0.34 and 8 . 4 8 ร— 1 0 2 M โˆ’ 1 s e c โˆ’ 1 , respectively. Linear sweep voltammetry was used for the determination of captopril in the presence of chlorpromazine. A linear calibration curve was obtained in the concentration range of captopril of 10.0–300.0 μM, with a limit of detection of 3.65 μM. The relative standard deviation (RSD%) for 5 replicate measurements of captopril (100 μM) was 1.96%. The method was applied to the determination of captopril in pharmaceutical formulations and blood serum samples with satisfactory results.