Differential Pulse Voltammetric Determination of Fulvestrant in Pharmaceutical Dosage Forms and Serum Samples

Table 1

Regression data of the calibration curve and quantitative determination of fulvestrant by DPV in standard solution and human serum.

	Standard solution	Serum
Measured potential (V)	0.83	0.84
Linearity range (M)	4×10^−6-6×10^−5	2×10^−5-1×10^−4
Slope (𝜇A M^−1)	5.34×10^4	8.21×10^3
Intercept (𝜇A)	2.78×10^−2	−5.22×10^−2
Correlation coefficient	0.998	0.999
SE of slope	1.60×10^3	1.06×10^2
SE of intercept	4.61×10^−2	7.00×10^−3
LOD (M)	5.40×10^−7	1.52×10^−6
LOQ (M)	1.80×10^−6	5.07×10^−6
Repeatability of peak current (RSD%)	0.93	0.51
Repeatability of peak potential (RSD%)	0.26	0.26
Reproducibility of peak current (RSD%)	1.68	0.72
Reproducibility of peak potential (RSD%)	0.26	0.32