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International Journal of Electrochemistry
Volume 2015, Article ID 151390, 5 pages
Research Article

A Novel Electrochemical Method for Protionamide Determination Based on Its Interaction with Alizarin Red S

Pharmacy College, Key Laboratory of Biomedical Engineering and Technology in Universities of Shandong, Qilu Medical University, Zibo 255213, China

Received 3 May 2015; Accepted 10 August 2015

Academic Editor: Adalgisa Rodrigues de Andrade

Copyright © 2015 Weili Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The interaction of protionamide with alizarin red S (ARS) and its analytical application were carefully investigated in this contribution. The interaction conditions were carefully studied and optimized by cyclic voltammetry. Under the optimum conditions, the cyclic voltammetry curve of ARS showed an oxidation peak with the peak potential of 0.57 V. After the addition of protionamide to the ARS solution, the peak potential was negatively moved, and meanwhile the oxidation peak current decreased apparently to the concentration of protionamide and then a new method for the protionamide determination was established. The linear equation between the decreasing current (Δip) and protionamide concentration was got as Δip (μA) = 0.01514 (mg/L) −0.01553   with the linear range of 10.0~50.0 mg/L, and the detection limit () was got as 8.25 μg/mL. The effects of coexisting substances on the determination were carefully investigated and the protionamide artificial and tablet samples were detected with satisfactory results.