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International Journal of Electrochemistry
Volume 2016, Article ID 1953278, 10 pages
Research Article

Electroanalytical Performance of a Carbon Paste Electrode Modified by Coffee Husks for the Quantification of Acetaminophen in Quality Control of Commercialized Pharmaceutical Tablets

1Electrochemistry and Chemistry of Materials, Department of Chemistry, University of Dschang, P.O. Box 67, Dschang, Cameroon
2L’UNAM, University of Angers, GEPEA UMR-CNRS 6144, 2 boulevard Lavoisier, 49045 Angers, France
3L’UNAM, University of Angers, GEIHP EA 3142, Institut de Biologie en Santé-IRIS, CHU, 4 rue Larrey, 49933 Angers, France
4Université de Toulouse, INP-ENSIACET, Laboratoire de Chimie Agro-Industrielle (LCA), 31030 Toulouse, France
5INRA, UMR 1010 CAI, 31030 Toulouse, France

Received 29 November 2015; Revised 24 February 2016; Accepted 8 March 2016

Academic Editor: Gerd-Uwe Flechsig

Copyright © 2016 Serge Foukmeniok Mbokou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Electrochemical determination of acetaminophen (APAP) was successfully performed using a carbon paste electrode (CPE) modified with coffee husks (CH-CPE). Scanning electron microscopy (SEM) and SEM-energy dispersive X-ray spectroscopy (SEM-EDX) were, respectively, used for the morphological and elemental characterization of coffee husks prior to their utilization. The electrochemical oxidation of APAP was investigated by cyclic voltammetry (CV), differential pulse voltammetry (DPV), and square wave voltammetry (SWV). SWV technique appeared to be more sensitive since the oxidation current of APAP was twofold higher with the CH-CPE sensor than with the bare CPE, in relation to the increase in the organophilic character of the electrode surface. Furthermore, on CH-CPE, the current response of APAP varied linearly with its concentration in the range of 6.6 μM to 0.5 mM, leading to a detection limit of 0.66 μM (). Finally, the proposed CH-CPE sensor was successfully used to determine the amount of APAP in commercialized tablets (Doliprane® 500 and Doliprane 1000), with a recovery rate ranging from 98% to 103%. This novel sensor opens the way for the development of low-cost and reliable devices for the electroanalysis of pharmaceutical formulations in developing countries.