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Comparative and Functional Genomics
Volume 2, Issue 3, Pages 169-175
Review Article

Definition of the Gene Content of the Human Genome: The Need for Deep Experimental Verification

The Ludwig Institute for Cancer Research, Rua Professor Antônio Prudente, 109, 4th floor, São Paulo, SP 01509-010, Brazil

Received 4 April 2001; Accepted 5 April 2001

Copyright © 2001 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Based on the analysis of the drafts of the human genome sequence, it is being speculated that our species may possess an unexpectedly low number of genes. The quality of the drafts, the impossibility of accurate gene prediction and the lack of sufficient transcript sequence data, however, render such speculations very premature. The complexity of human gene structure requires additional and extensive experimental verification of transcripts that may result in major revisions of these early estimates of the number of human genes.