Synthetic Peptide and Protein Domain Arrays Prepared by the SPOT Technology

Schneider-Mergener, Jens

doi:https://doi.org/10.1002/cfg.99

International Journal of Genomics

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Conference Review | Open Access

Volume 2 |Article ID 756761 | https://doi.org/10.1002/cfg.99

Jens Schneider-Mergener, "Synthetic Peptide and Protein Domain Arrays Prepared by the SPOT Technology", International Journal of Genomics, vol. 2, Article ID 756761, 3 pages, 2001. https://doi.org/10.1002/cfg.99

Synthetic Peptide and Protein Domain Arrays Prepared by the SPOT Technology

Jens Schneider-Mergener^1,2

¹Institut für Medizinische Immunologie, Universitätsklinikum Charité, Humboldt Universität zu Berlin, Germany

²Jerini AG, Rudower Chausse 29, Germany

Received22 Jun 2001

Accepted27 Jul 2001

Abstract

The SPOT™ technology for highly parallel synthesis of peptides on flat surfaces in array type format has evolved into a versatile toolbox for a variety of applications in proteomics such as mapping protein-protein interactions and profiling the substrate specificity of enzymes such as kinases and proteases. Originally developed for the synthesis of short overlapping peptide sequences for mapping antibody epitopes this technology has recently been extended to the synthesis of functional protein domains. This opens up a variety of future applications such as target identification and protein expression profiling.

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Copyright © 2001 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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