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Comparative and Functional Genomics
Volume 2, Issue 1, Pages 22-24
Conference Paper

From Genome to Function: Systematic Analysis of the Soil Bacterium Bacillus subtilis

1Department of Microbiology and Immunology, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
2Department of Agricultural and Environmental Sciences, University of Newcastle upon Tyne, King George VI Building, Newcastle upon Tyne NE1 7RU, UK

Copyright © 2001 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Bacillus subtilis is a sporulating Gram-positive bacterium that lives primarily in the soil and associated water sources. Whilst this bacterium has been studied extensively in the laboratory, relatively few studies have been undertaken to study its activity in natural environments. The publication of the B. subtilis genome sequence and subsequent systematic functional analysis programme have provided an opportunity to develop tools for analysing the role and expression of Bacillus genes in situ. In this paper we discuss analytical approaches that are being developed to relate genes to function in environments such as the rhizosphere.