International Journal of Genomics

International Journal of Genomics / 2002 / Article

Conference Review | Open Access

Volume 3 |Article ID 493750 |

Graham R. Stewart, Lorenz Wernisch, Richard Stabler, Joseph A. Mangan, Jason Hinds, Ken G. Laing, Philip D. Butcher, Douglas B. Young, "The Heat Shock Response of Mycobacterium tuberculosis: Linking Gene Expression, Immunology and Pathogenesis", International Journal of Genomics, vol. 3, Article ID 493750, 4 pages, 2002.

The Heat Shock Response of Mycobacterium tuberculosis: Linking Gene Expression, Immunology and Pathogenesis

Received31 May 2002
Accepted10 Jun 2002


The regulation of heat shock protein (HSP) expression is critically important to pathogens such as Mycobacterium tuberculosis and dysregulation of the heat shock response results in increased immune recognition of the bacterium and reduced survival during chronic infection. In this study we use a whole genome spotted microarray to characterize the heat shock response of M. tuberculosis. We also begin a dissection of this important stress response by generating deletion mutants that lack specific transcriptional regulators and examining their transcriptional profiles under different stresses. Understanding the stimuli and mechanisms that govern heat shock in mycobacteria will allow us to relate observed in vivo expression patterns of HSPs to particular stresses and physiological conditions. The mechanisms controlling HSP expression also make attractive drug targets as part of a strategy designed to enhance immune recognition of the bacterium.

Copyright © 2002 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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