International Journal of Genomics

International Journal of Genomics / 2003 / Article

Primary research paper | Open Access

Volume 4 |Article ID 421846 | https://doi.org/10.1002/cfg.317

John McClure, Ernst Wit, "Post-Normalization Quality Assessment Visualization of Microarray Data", International Journal of Genomics, vol. 4, Article ID 421846, 8 pages, 2003. https://doi.org/10.1002/cfg.317

Post-Normalization Quality Assessment Visualization of Microarray Data

Received01 Mar 2003
Revised17 Jun 2003
Accepted22 Jul 2003

Abstract

Post-normalization checking of microarrays rarely occurs, despite the problems that using unreliable data for inference can cause. This paper considers a number of different ways to check microarrays after normalization for a variety of potential problems. Four types of problem with microarray data that these checks can identify are: clerical mistakes, array-wide hybridization problems, problems with normalization and mishandling problems. Any of these can seriously affect the results of any analysis. The three main techniques used to identify these problems are dimension reduction techniques, false array plots and correlograms. None of the techniques are computationally very intensive and all can be carried out in the R statistical package. Once discovered, problems can either be rectified or excluded from the data.

Copyright © 2003 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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